Agent Name

Perchloryl fluoride

CAS Number

7616-94-6

Formula

Cl-F-O3

Major Category

Toxic Gases & Vapors

Synonyms

Chlorine fluoride oxide; Chlorine fluoride oxide (ClO3F); Chlorine oxyfluoride; Chloryl (per-)fluoride; Perchloryl fluoride; [ChemIDplus] UN3083

Category

Oxidizers

Description

Colorless gas with a characteristic, sweet odor. [Note: Shipped as a liquefied compressed gas.]; [NIOSH]

Sources/Uses

Used as "a fluorinating agent in chemical syntheses and as a liquid oxidant in rocket fuels." [ACGIH]

Comments

In acute animal studies, methemoglobinemia, as high as 71%, is the prominent effect from exposure to the vapor. In subchronic inhalation studies, methemoglobinemia, fluorosis, liver and kidney injury, and pulmonary edema are observed. Listed in the table "Examples of Industrial Chemicals for Which Methemoglobin Formation is NOT the Principal Cause of Toxicity"; [ACGIH] Possible frostbite from contact with liquid; [NIOSH] May cause respiratory tract irritation and pulmonary edema; Can induce methemoglobinemia; May cause fluorosis; [ICSC] See "FLUORIDES."

Exposure Assessment
Skin Designation (ACGIH)

Insufficient data

TIH

Yes

TLV (ACGIH)

3 ppm

STEL (ACGIH)

6 ppm

PEL (OSHA)

3 ppm

IDLH (NIOSH)

100 ppm

Excerpts from Documentation for IDLHs

"Dogs, rats, and mice exposed to perchloryl fluoride vapor developed methemoglobinemia. Dogs exposed to the vapor at 220 to 450 ppm for 4 hours and at 620 ppm for 2.5 hours were cyanotic and hyperpneic; methemoglobin values ranged from 29% to 71%. In dogs that died due to inhaled perchloryl fluoride, there were areas of pigment deposition in the liver, spleen, and bone marrow; areas of alveolar hemorrhage, alveolar collapse, and emphysema were also noted." [ACGIH] ?NIOSH vs ACGIH

Odor Threshold Low

10 ppm

Lethal Concentration

LC50 (rat) = 385 ppm/4H

Explanatory Notes

Odor threshold from "Quick Guide: The Electronic NIOSH Pocket Guide to Chemical Hazards";

Reference Link

ICSC: Perchloryl fluoride

Adverse Effects
Toxic Pneumonitis

Yes

Hepatotoxin

Hepatotoxin, Secondary

Methemoglobinemia

Methemoglobinemia, Secondary

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent: