Agent Name

Phenyl ether

Alternative Name

Diphenyl ether

CAS Number

101-84-8

Formula

C12-H10-O

Major Category

Other Classes

Synonyms

1,1'-Oxybis(benzene); Benzene, 1,1'-oxybis-; Benzene, phenoxy-; Biphenyl oxide; Chemcryl JK-EB; Diphenyl ether; Diphenyl oxide; Ether, diphenyl-; Geranium crystals; Oxybisbenzene; Oxydiphenyl; Phenoxybenzene; Phenyl oxide; [ChemIDplus] UN3077

Category

Other Aromatic Compounds

Description

Colorless, crystalline solid or liquid (above 82 degrees F) with a geranium-like odor; [NIOSH] Disagreeable odor; [ACGIH]

Sources/Uses

Used as a heat transfer medium, Dowtherm A, and as a chemical intermediate for surface active agents and lubricants; [ACGIH]

Comments

. . . industrial experience has shown no evidence that phenyl ether, either as liquid mist or vapor, was a human health hazard under ordinary conditions of manufacture, handling, or use. Controlling workplace concentration below 1 ppm has been recommended to prevent the disagreeable odor and nausea in some workers. Damage to the liver and other organs has been documented in acute feeding studies of experimental animals; LD50 = 4 g/kg for rats and guinea pigs; [ACGIH] An irritant of the eyes and respiratory tract; [ICSC]

Exposure Assessment
Skin Designation (ACGIH)

Insufficient data

TLV (ACGIH)

1 ppm, vapor fraction

STEL (ACGIH)

2 ppm, vapor fraction

PEL (OSHA)

1 ppm

MAK

1 ppm

IDLH (NIOSH)

100 ppm

Excerpts from Documentation for IDLHs

Other animal data: Rats exposed to 20 ppm for 7 hours per day for 20 days exhibited only eye and nasal irritation [Hefner et al. 1975]. Human data: It has been reported that industrial experience has shown no evidence that phenyl ether, either as a liquid, mist, or vapor, is a health hazard under ordinary conditions of production and use; no overt systemic toxicity was found at concentrations that were not intolerably disagreeable [Clayton and Clayton 1981].

Vapor Pressure

0.02 mm Hg

Odor Threshold Low

0.0012 ppm

Explanatory Notes

Reported odor threshold; [ACGIH] Flash point = 115 deg C;

Adverse Effects
Hepatotoxin

Hepatotoxin, Secondary

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Related Information in HazMap
Other Information

No other related information on this agent was found.