Agent Name

Mecarbam

CAS Number

2595-54-2

Formula

C10-H20-N-O5-P-S2

Major Category

Pesticides

Synonyms

AFOS; Criotox; Dithiophosphate de O,O-diethyle et de S-N-methyl N-carboethoxy carbamoylmethyle [French]; Ethyl (diethoxyphosphinothioylthio)acetyl(methyl)carbamate; Ethyl (mercaptoacetyl)methylcarbamate S-ester with O,O-diethyl phosphorodithioate; Ethyl 6-ethoxy-2-methyl-3-oxo-7-oxa-5-thia-2-aza-6-phosphanonanoate 6-sulfide; Ethyl N-(diethoxythiophosphorylthio)acetyl-N-methylcarbamate; Ethyl(((diethoxyphosphinothioyl)thio)acetyl)methylcarbamate; MC 474; MS 1053; MS 1143; Marfotoks; Mecarbame [ISO-French]; Mercarbam; Murfotox; Murphotox; N-Ethoxycarbonyl-N-methylcarbamoylmethyl O,O-diethyl phosphorodithioate; O,O-Diaethyl-S-(3-methyl-2,4-dioxo-5-oxa-3-aza-heptyl)-dithiophosphat [German]; O,O-Diethyl S-(((ethoxycarbonyl)methylcarbamoyl)methyl) phosphorodithioate; O,O-Diethyl S-(N-ethoxycarbonyl-N-methylcarbamoylmethyl) phosphorodithioate; O,O-Diethyl S-(N-ethoxycarbonyl-N-methylcarbamoylmethyl) phosphorothiolothionate; O,O-Diethyl S-(N-ethoxycarbonyl-N-methylcarbamoylmethyl)phosphorodithioate; O,O-Diethyl S-(N-ethoxycarbonyl-N-methylcarbamoylmethyl)phosphorothiolothionate; O,O-Diethyl S-(N-methyl-N-carboethoxycarbamoylmethyl) dithiophosphate; O,O-Diethyl S-(N-methyl-N-carboethoxycarbamoylmethyl)dithiophosphate; O,O-Diethyl-S-(3-methyl-2,4-dioxo-5-oxa-3-aza-heptyl)-dithiofosfaat [Dutch]; O,O-Dietil-S-(N-etossi-carbonil-N-metil-carbamoil-metil)-ditiofosfato [Italian]; P 474; Pennsalt TD-72; Pestan; Phosphorodithioic acid, O,O-diethyl ester, S-ester with ethyl (mercaptoacetyl)methylcarbamate; S-((Ethoxycarbonyl)methylcarbamoyl)methyl O,O-diethyl phosphorodithioate; S-(N-Ethoxycarbonyl-N-methylcarbamoylmethyl) O,O-diethyl phosphorodithioate; S-(N-Ethoxycarbonyl-N-methylcarbamoylmethyl)-diethyl phosphorodithioate; TD 72; [ChemIDplus] UN3018

Category

Organophosphate Insecticides

Description

Colorless or light brown to pale yellow liquid; [HSDB] Light yellow oily liquid; [MSDSonline]

Sources/Uses

Used as insecticide and acaricide for rice, tea, fruits, and vegetables; [HSDB]

Comments

Very toxic cholinesterase inhibitor; May be restrictions on use; [Hawley] Has caused delayed neuropathy in humans; Depressed cholinesterase activity in animal studies by ingestion and inhalation; No gross or histopathological changes observed in two year feeding study with dogs; No evidence of reproductive or teratogenic effects in study with rats; [HSDB] Effects in dermal exposure study with rats include reduced growth rate and food consumption, inhibition of cholinesterase activity, and hematological changes (females); No adverse histopathological changes observed; No evidence of teratogenicity or delayed neurotoxicity in animal studies; [Reference #1] A severe skin irritant; [MSDSonline] The average of two baseline respective cholinesterase activity determinations three days apart, with no exposures to enzyme inhibiting pesticides for at least 30 days, is recommended for each worker prior to exposure to cholinesterase inhibitors because of large inter-individual differences in published baseline values. To be established at least once a year. Removal from workplace exposures is recommended until the cholinesterase activity returns to within 20% of baseline. [TLVs and BEIs]

Reference Link

INCHEM JMPR: Mecarbam - 1986

Exposure Assessment
BEI

Acetylcholinesterase activity in red blood cells = 70% of individual's baseline; Butylcholinesterase activity in serum or plasma = 60% of individual's baseline; Sample at end of shift; [TLVs and BEIs]

Lethal Concentration

LC50 (rat) = 700 mg/m3/6h

Explanatory Notes

The Guide in the Emergency Response Guidebook is for "Organophosphorus pesticide, liquid, toxic."

Adverse Effects
Neurotoxin

Motor Neuropathy

Other Poison

Organophosphate

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Biomedical References

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure: