Agent Name

Menthone

CAS Number

89-80-5

Formula

C10-H18-O

Major Category

Biological Agents

Synonyms

5-Methyl-2-(1-methylethyl)cyclohexanone, trans-; Cyclohexanone, 5-methyl-2-(1-methylethyl)-, trans-; Menthone (natural); Neomenthone; p-Menthan-3-one, trans-; p-Menthone; trans-Menthan-3-one; [ChemIDplus]

Category

Plant Oils and Extracts

Description

Colorless liquid with a mild odor of peppermint; [Hawley]

Sources/Uses

Ketone present in peppermint oil; [Hawley] Used in perfumes and flavorings; [HSDB] Peppermint oil contains menthol, menthone, and more than 30 other chemicals. It is widely used as a flavoring agent and herbal remedy. [Haddad, p. 1439]

Comments

Emergency treatment: "Peppermint oil"; A mild skin irritant in rabbits; After oral dosing at 400-800 mg/kg/day for 28 days, rats have liver and kidney dysfunction and histopathological cysts in the white matter of the cerebellum; [HSDB] Peppermint oil causes CNS depression and hypothermia in rat feeding studies; [Haddad, p. 1439] Safe when used as a flavoring agent in food; [JECFA]

Exposure Assessment
Vapor Pressure

0.27 mm Hg

Adverse Effects
Neurotoxin

Other CNS Neurotoxin

Hepatotoxin

Hepatotoxin, Secondary

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Other Information

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