Agent Name

Phosphorus oxychloride

CAS Number

10025-87-3

Formula

Cl3-O-P

Major Category

Toxic Gases & Vapors

Synonyms

Fosforoxychlorid [Czech]; Oxychlorid fosforecny [Czech]; Phosphoric trichloride; Phosphoroxychloride; Phosphorus chloride oxide (POCl3); Phosphorus oxide trichloride; Phosphorus oxychloride; Phosphorus oxytrichloride; Phosphoryl chloride; Phosphoryl trichloride; Trichlorophosphine oxide; Trichlorophosphorus oxide; [ChemIDplus] UN1810

Category

Acid Halides

Description

Clear, colorless to yellow, oily liquid with a pungent & musty odor. [Note: A solid below 34 degrees F.]; [NIOSH]

Sources/Uses

Used in chemical synthesis as a chlorinating agent and catalyst and to produce plasticizers, hydraulic fluids, gasoline additives, and fire retardants; [ACGIH]

Comments

Liquid causes second or third degree burns after short contact; [CHRIS] Highly corrosive to skin; [Quick CPC] Mucous membrane irritation, bronchitis, pulmonary edema, and nephritis have been reported after occupational exposure. [ACGIH] Liver injury in animals in a chronic study; [Desai, H. Phosphorus and Phosphorus Compounds. In: Sullivan J, Krieger G (eds). Hazardous Materials Toxicology.Baltimore:Williams & Wilkins,1992;939] A corrosive substance that can cause pulmonary edema; [ICSC] A lachrymator; [CHEMINFO]

Exposure Assessment
Skin Designation (ACGIH)

Insufficient data

TIH

Yes

Dangerous When Wet

Yes - A material that, by contact with water, is liable to become spontaneously flammable or to give off flammable or toxic gas at a rate greater than 1 L per kilogram of the material, per hour; [ERG 2004]

TLV (ACGIH)

0.1 ppm

MAK

0.02 ppm

Lethal Concentration

LC50 (rat) = 32 ppm/4h

Explanatory Notes

VP = 40 mmHg @ 81 deg F; [Sax]

Reference Link

ICSC: Phosphorus oxychloride

Adverse Effects
Lacrimator

Yes

Toxic Pneumonitis

Yes

Hepatotoxin

Hepatotoxin, Secondary

Nephrotoxin

Yes

Dermatotoxin

Skin Burns

Links to Other NLM Databases
Health Studies

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Toxicity Information

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Chemical Information

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Biomedical References

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure: