Agent Name

Phosphorus trichloride

CAS Number

7719-12-2

Formula

Cl3-P

Major Category

Toxic Gases & Vapors

Synonyms

Fosforo(tricloruro di) [Italian]; Fosfortrichloride [Dutch]; Phosphine, trichloro-; Phosphore(trichlorure de) [French]; Phosphorous chloride; Phosphorous trichloride; Phosphortrichlorid [German]; Phosphorus chloride (Cl6P2); Phosphorus chloride (PCl3); Trichlorophosphine; Trojchlorek fosforu [Polish; [ChemIDplus] UN1809

Category

Other Toxic Gases & Vapors

Description

Colorless to yellow, fuming liquid with an odor like hydrochloric acid; [NIOSH]

Sources/Uses

Used to produce pesticides, gasoline additives, plasticizers, dyes, and textile-finishing agents; also used as a chlorine donor and catalyst in chemical reactions; [ACGIH]

Comments

Liquid causes second or third degree burns after short contact; [CHRIS] Highly corrosive to skin; [Quick CPC] Rats develop nephrosis and pulmonary edema after 4 hour exposures in the range of 100 ppm; 23 workers exposed to 1.8 to 27 ppm complained of eye and throat irritation; mild bronchitis was common and irritant asthma developed in some of the workers; [ACGIH] Toxic to the liver in a chronic study of animals; [Desai, H. Phosphorus and Phosphorus Compounds. In: Sullivan J, Krieger G (eds).Hazardous Materials Toxicology.Baltimore:Williams & Wilkins,1992;939] A corrosive substance that can cause pulmonary edema; [ICSC] A lachrymator; [CHEMINFO]

Exposure Assessment
Skin Designation (ACGIH)

Insufficient data

TIH

Yes

Dangerous When Wet

Yes - A material that, by contact with water, is liable to become spontaneously flammable or to give off flammable or toxic gas at a rate greater than 1 L per kilogram of the material, per hour; [ERG 2004]

TLV (ACGIH)

0.2 ppm

STEL (ACGIH)

0.5 ppm

PEL (OSHA)

0.5 ppm

MAK

0.1 ppm

IDLH (NIOSH)

25 ppm

Excerpts from Documentation for IDLHs

Other animal data: Cats and guinea pigs exposed for 6 hours at 0.7 ppm showed only mild signs of intoxication and a 1hour exposure at 2 to 4 ppm failed to produce severe signs of poisoning; however, a single 1hour exposure at 50 to 90 ppm resulted in serious disturbances [Butjagin 1904]. . . . Human data: Workers exposed to concentrations ranging from 1.8 to 27 ppm had symptoms that included burning of the eyes and throat, irritation of the pharyngeal mucous membranes, and mild bronchitis within 2 to 6 hours after exposure [Sassi 1952].

Vapor Pressure

100 mm Hg

Lethal Concentration

LC50 (rat) = 104 ppm/4 hr

Adverse Effects
Lacrimator

Yes

Toxic Pneumonitis

Yes

Hepatotoxin

Hepatotoxin, Secondary

Nephrotoxin

Yes

Dermatotoxin

Skin Burns

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure: