| Agent Name | Phosphorus trichloride |
|---|---|
| CAS Number | 7719-12-2 |
| Formula | Cl3-P |
| Major Category | Toxic Gases & Vapors |
| Synonyms | Fosforo(tricloruro di) [Italian]; Fosfortrichloride [Dutch]; Phosphine, trichloro-; Phosphore(trichlorure de) [French]; Phosphorous chloride; Phosphorous trichloride; Phosphortrichlorid [German]; Phosphorus chloride (Cl6P2); Phosphorus chloride (PCl3); Trichlorophosphine; Trojchlorek fosforu [Polish; [ChemIDplus] UN1809 |
| Category | Other Toxic Gases & Vapors |
| Description | Colorless to yellow, fuming liquid with an odor like hydrochloric acid; [NIOSH] |
| Sources/Uses | Used to produce pesticides, gasoline additives, plasticizers, dyes, and textile-finishing agents; also used as a chlorine donor and catalyst in chemical reactions; [ACGIH] |
| Comments | Liquid causes second or third degree burns after short contact; [CHRIS] Highly corrosive to skin; [Quick CPC] Rats develop nephrosis and pulmonary edema after 4 hour exposures in the range of 100 ppm; 23 workers exposed to 1.8 to 27 ppm complained of eye and throat irritation; mild bronchitis was common and irritant asthma developed in some of the workers; [ACGIH] Toxic to the liver in a chronic study of animals; [Desai, H. Phosphorus and Phosphorus Compounds. In: Sullivan J, Krieger G (eds).Hazardous Materials Toxicology.Baltimore:Williams & Wilkins,1992;939] A corrosive substance that can cause pulmonary edema; [ICSC] A lachrymator; [CHEMINFO] |
| Exposure Assessment | |
| Skin Designation (ACGIH) | Insufficient data |
| TIH | Yes |
| Dangerous When Wet | Yes - A material that, by contact with water, is liable to become spontaneously flammable or to give off flammable or toxic gas at a rate greater than 1 L per kilogram of the material, per hour; [ERG 2004] |
| TLV (ACGIH) | 0.2 ppm |
| STEL (ACGIH) | 0.5 ppm |
| PEL (OSHA) | 0.5 ppm |
| MAK | 0.1 ppm |
| IDLH (NIOSH) | 25 ppm |
| Excerpts from Documentation for IDLHs | Other animal data: Cats and guinea pigs exposed for 6 hours at 0.7 ppm showed only mild signs of intoxication and a 1hour exposure at 2 to 4 ppm failed to produce severe signs of poisoning; however, a single 1hour exposure at 50 to 90 ppm resulted in serious disturbances [Butjagin 1904]. . . . Human data: Workers exposed to concentrations ranging from 1.8 to 27 ppm had symptoms that included burning of the eyes and throat, irritation of the pharyngeal mucous membranes, and mild bronchitis within 2 to 6 hours after exposure [Sassi 1952]. |
| Vapor Pressure | 100 mm Hg |
| Lethal Concentration | LC50 (rat) = 104 ppm/4 hr |
| Explanatory Notes | Some Water Reactive Materials are also TIH materials themselves: Phosphorus trichloride; [ERG 2016] |
| Adverse Effects | |
| Lacrimator | Yes |
| Toxic Pneumonitis | Yes |
| Hepatotoxin | Hepatotoxin, Secondary |
| Nephrotoxin | Yes |
| Dermatotoxin | Skin Burns |
| Links to Other NLM Databases | |
| Health Studies | Human Health Effects from Hazardous Substances Data Bank: |
| Toxicity Information | |
| Chemical Information | |
| Related Information in HazMap | |
| Diseases | Occupational diseases associated with exposure to this agent: |
| Processes | Industrial Processes with risk of exposure: |
Agent Name
Phosphorus trichloride
CAS Number
7719-12-2
Formula
Cl3-P
Major Category
Toxic Gases & Vapors
Synonyms
Fosforo(tricloruro di) [Italian]; Fosfortrichloride [Dutch]; Phosphine, trichloro-; Phosphore(trichlorure de) [French]; Phosphorous chloride; Phosphorous trichloride; Phosphortrichlorid [German]; Phosphorus chloride (Cl6P2); Phosphorus chloride (PCl3); Trichlorophosphine; Trojchlorek fosforu [Polish; [ChemIDplus] UN1809
Category
Other Toxic Gases & Vapors
Description
Colorless to yellow, fuming liquid with an odor like hydrochloric acid; [NIOSH]
Sources/Uses
Used to produce pesticides, gasoline additives, plasticizers, dyes, and textile-finishing agents; also used as a chlorine donor and catalyst in chemical reactions; [ACGIH]
Comments
Liquid causes second or third degree burns after short contact; [CHRIS] Highly corrosive to skin; [Quick CPC] Rats develop nephrosis and pulmonary edema after 4 hour exposures in the range of 100 ppm; 23 workers exposed to 1.8 to 27 ppm complained of eye and throat irritation; mild bronchitis was common and irritant asthma developed in some of the workers; [ACGIH] Toxic to the liver in a chronic study of animals; [Desai, H. Phosphorus and Phosphorus Compounds. In: Sullivan J, Krieger G (eds).Hazardous Materials Toxicology.Baltimore:Williams & Wilkins,1992;939] A corrosive substance that can cause pulmonary edema; [ICSC] A lachrymator; [CHEMINFO]
Exposure Assessment
Skin Designation (ACGIH)
Insufficient data
TIH
Yes
Dangerous When Wet
Yes - A material that, by contact with water, is liable to become spontaneously flammable or to give off flammable or toxic gas at a rate greater than 1 L per kilogram of the material, per hour; [ERG 2004]
TLV (ACGIH)
0.2 ppm
STEL (ACGIH)
0.5 ppm
PEL (OSHA)
0.5 ppm
MAK
0.1 ppm
IDLH (NIOSH)
25 ppm
Excerpts from Documentation for IDLHs
Other animal data: Cats and guinea pigs exposed for 6 hours at 0.7 ppm showed only mild signs of intoxication and a 1hour exposure at 2 to 4 ppm failed to produce severe signs of poisoning; however, a single 1hour exposure at 50 to 90 ppm resulted in serious disturbances [Butjagin 1904]. . . . Human data: Workers exposed to concentrations ranging from 1.8 to 27 ppm had symptoms that included burning of the eyes and throat, irritation of the pharyngeal mucous membranes, and mild bronchitis within 2 to 6 hours after exposure [Sassi 1952].
Vapor Pressure
100 mm Hg
Lethal Concentration
LC50 (rat) = 104 ppm/4 hr
Explanatory Notes
Some Water Reactive Materials are also TIH materials themselves: Phosphorus trichloride; [ERG 2016]
Adverse Effects
Lacrimator
Yes
Toxic Pneumonitis
Yes
Hepatotoxin
Hepatotoxin, Secondary
Nephrotoxin
Yes
Dermatotoxin
Skin Burns
Links to Other NLM Databases
Toxicity Information
Chemical Information
Related Information in HazMap
Processes
Industrial Processes with risk of exposure: