Disease/Syndrome

Cadmium, chronic toxic effect

Category

Metal Poisoning, Occupational

Acute/Chronic

Chronic

Synonyms

Itai-itai disease

Biomedical References

Search PubMed

Comments

Acutely, cadmium exposure can cause delayed pulmonary edema and acute renal failure after inhalation of high concentrations of the fume. See "Pneumonitis, toxic." See "Acute tubular necrosis." Chronically, cadmium dust and fume are toxic primarily to the kidneys with secondary effects on the bones (osteomalacia). Biological monitoring of cadmium exposed workers is mandated by OSHA to prevent chronic renal disease. [LaDou, p. 467-9] Studies of heavily exposed workers have shown a latency of about 10 years before the onset of kidney damage. [ATSDR Case Studies #10, p. 7]

Latency/Incubation

Weeks to years

Diagnostic

Urine and blood cadmium; Urine B2-microglobulins; When urinary cadmium level is less 10 micrograms/g. creatinine, then renal dysfunction is unlikely.

ICD-9 Code

985.5

Reference Link

OSHA - Cadmium

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Job Tasks

High risk job tasks associated with this disease:

Agents

Hazardous agents that cause the occupational disease: