Agent Name

CHLORINATED DIBENZOFURANS

Alternative Name

CLASS

Major Category

Other Classes

Synonyms

CLASSES; Chlorodibenzofurans; CDFs; Chlorodibenzofuran; [ChemFinder]

Category

Halogenated Polyaromatics

Description

Colorless solids not soluble in water; [ATSDR ToxFAQs]

Sources/Uses

May contaminate polychlorinated biphenyl (PCB) compounds; CDFs have been found in fly ash from municipal incinerators; [LaDou, p. 517-8]

Comments

Polychlorodibenzofurans can induce chloracne. [Rosenstock, p. 714] "Chlorinated dibenzofurans, or CDFs, are a family of chemicals that contain one to eight chlorine atoms attached to the carbon atoms of the parent chemical, dibenzofuran. There are 135 different types of CDFs with varying harmful health and environmental effects." Chloracne and liver toxicity are associated with exposure to these agents, e.g., the Yusho incident in Japan in 1968 involving people who consumed rice oil contaminated with PCBs and CDFs. Reproductive effects in Yusho patients incuded irregular menstrual periods in exposed mothers, decreased mean birth weights, and lower developmental scores in children; [ATSDR TOXFAQs]

Reference Link

IARC 2012: 2,3,4,7,8-Pentachlorodibenzofuran

Exposure Assessment
Bioaccumulates

Yes

Reference Link

ATSDR - ToxFAQs - Chlorodibenzofurans (CDFs)

Adverse Effects
Hepatotoxin

Hepatotoxin, Secondary

Reproductive Toxin

Yes

Dermatotoxin

Chloracne

IARC Carcinogen

Not Classifiable

Links to Other NLM Databases
Toxicity Information

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Chemical Information

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Biomedical References

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent: