Agent Name

Methanesulfonyl fluoride

CAS Number

558-25-8

Formula

C-H3-F-O2-S

Major Category

Toxic Gases & Vapors

Synonyms

Fluoro methyl sulfone; Fumette; MSF; Mesyl fluoride; Methanesulphonyl fluoride; [ChemIDplus] UN2927

Category

Acid Halides

Description

Liquid; [CAMEO] Colorless liquid with a pungent odor; [MSDSonline]

Sources/Uses

Used formerly as fumigant insecticide; Used in medical research; [HSDB]

Comments

Highly corrosive; May cause serious injury to skin, eyes, mucous membranes, and upper respiratory tract; Inhalation may cause chemical pneumonitis and pulmonary edema; A selective inhibitor of CNS acetylcholinesterase; Sex-specific changes in brain development were observed in rats chronically exposed in utero; [HSDB] Reacts with water evolving hydrogen fluoride gas; Corrosive; Highly toxic by inhalation; [CAMEO] Effects in high-dose animal studies include inhibition of true cholinesterase and degenerative changes to brain; [RTECS]

Exposure Assessment
BEI

Fluorides in urine = 2 mg/L prior to shift or 3 mg/L at end of shift; (Repeated measurements recommended.)

TLV (ACGIH)

2.5 mg/m3, as F

PEL (OSHA)

2.5 mg/m3, as F

MAK

1 mg/m3, as F, inhalable fraction

Vapor Pressure

10.9 mm Hg

Lethal Concentration

LC50 (rat) = 1 ppm/7h

Explanatory Notes

The Guide in the Emergency Response Guidebook is for "Toxic liquid, corrosive, organic, n.o.s. (Inhalation Hazard Zone A)."

Adverse Effects
Toxic Pneumonitis

Yes

Dermatotoxin

Skin Burns

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Related Information in HazMap
Processes

Industrial Processes with risk of exposure: