Agent Name

Piperazine dihydrochloride

CAS Number

142-64-3

Formula

C4-H10-N2.2Cl-H

Major Category

Nitrogen Compounds

Synonyms

Diethylenediamine dihydrochloride; Dihydro Pip Wormer; Dihydrochloride salt of diethylenediamine; Dowzene DHC; Piperazine dihydrochloride; Piperazine wormer premix; [ChemIDplus]

Category

Piperazines

Description

White to cream-colored needles or powder; [NIOSH]

Sources/Uses

Used to manufacture fibers, pharmaceuticals, and insecticides; [ACGIH] Used as a veterinary antihelmintic medication and a curing agent for polychloroprene; [HSDB]

Comments

Piperazine dihydrochloride is well tolerated as an oral medication at a dose of 150 mg/kg for several days. Skin burns, allergic contact dermatitis, and asthma have been reported after occupational exposures to piperazine dust. [ACGIH] Piperazine, CAS # 110-85-0, is corrosive to skin. [Quick CPC] Asthma reported in pharmaceutical and chemical production workers; [Malo] Allergic contact dermatitis reported in pharmaceutical, laboratory, healthcare, and veterinary workers; [Kanerva, p. 1827] See "Piperazine and salts."

Reference Link

Piperazine-induced occupational asthma

Exposure Assessment
Explanatory Notes

TLV withdrawn 2012;

Adverse Effects
Skin Sensitizer

Yes

Asthma

Yes

Dermatotoxin

Skin Burns

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Biomedical References

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure: