Agent Name

n-Propyl acetate

CAS Number

109-60-4

Formula

C5-H10-O2

Major Category

Solvents

Synonyms

1-Acetoxypropane; 1-Propyl acetate; Acetate de propyle normal [French]; Acetic acid n-propyl ester; Acetic acid, propyl ester; Octan propylu [Polish]; Propyl acetate; Propyl ethanoate; Propylester kyseliny octove [Czech]; n-Propyl acetate; n-Propyl acetate (natural); n-Propyl ethanoate; [ChemIDplus] UN1276

Category

Esters (<C12)

Description

Colorless liquid with a mild, fruity odor; [NIOSH]

Sources/Uses

Used as a solvent, flavoring agent, and chemical intermediate; [ACGIH]

Comments

Esters may induce narcosis in animals, but workers' exposures are limited by irritating effects. See appendix in: [Dick RB, et al. Chemicals in the workplace: incorporating human neurobehavioral testing into the regulatory process. Am J Ind Med. 1998 May;33(5):439-53.] A skin, eye, and respiratory tract irritant; Inhalation of high concentrations can cause CNS depression; [ICSC]

Exposure Assessment
Skin Designation (ACGIH)

Insufficient data

TLV (ACGIH)

200 ppm

STEL (ACGIH)

250 ppm

PEL (OSHA)

200 ppm

MAK

100 ppm

IDLH (NIOSH)

1700 ppm

Excerpts from Documentation for IDLHs

Basis for original (SCP) IDLH: The chosen IDLH is based on the statement by ACGIH [1971] that a 4hour exposure to 8,000 ppm was fatal to 4 of 6 rats [Smyth et al. 1954]. . . . Human data: None relevant for use in determining the revised IDLH.

Vapor Pressure

35.9 mm Hg

Odor Threshold Low

0.04 ppm

Odor Threshold High

0.7 ppm

Lethal Concentration

LCLo (rat) = 8,000 ppm/4H

Explanatory Notes

Detection odor threshold from AIHA (mean = 0.18 ppm); Flash point = 14 deg C; See "2017 Notice of Intended Changes." [TLVs and BEIs]

Flammability (NFPA)

3: May ignite at ambient temperature

Adverse Effects
Neurotoxin

CNS Solvent Syndrome

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure: