Agent Name

n-Propyl nitrate

CAS Number

627-13-4

Formula

C3-H7-N-O3

Major Category

Nitrogen Compounds

Synonyms

Monopropyl nitrate; Nitrate de propyle normal [French]; Nitric acid, propyl ester; Propyl nitrate; Propylester kyseliny dusicne [Czec]; [ChemIDplus] UN1865

Category

Nitrates and Nitrites

Description

Colorless to straw-colored liquid with an ether-like odor; [NIOSH]

Sources/Uses

Used to promote fuel ignition and to synthesize organic chemicals; [ACGIH]

Comments

Induces methemoglobinemia in experimental animals at high concentrations; Methemoglobinemia is unlikely in workers because lower concentrations provoke nausea, headache and avoidance of irritating effects; [ACGIH] n-Propyl nitrate is in the ACGIH list of "Industrial Chemicals for Which Methemoglobin Formation is the Principal Cause of Toxicity" A skin, eye, and respiratory tract irritant; Can induce methemoglobinemia; [ICSC]

Exposure Assessment
BEI

Methemoglobin in blood = 1.5% of hemoglobin during or at end of shift. [ACGIH]

Skin Designation (ACGIH)

Insufficient data

TLV (ACGIH)

25 ppm

STEL (ACGIH)

40 ppm

PEL (OSHA)

25 ppm

IDLH (NIOSH)

500 ppm

Excerpts from Documentation for IDLHs

Basis for original (SCP) IDLH The chosen IDLH is based on the statement by ACGIH [1971] that the dog 4hour LC50 is 2,000 to 2,500 ppm [Rinehart et al. 1958]. . . . Human data None relevant for use in determining the revised IDLH.

Vapor Pressure

23.5 mm Hg

Odor Threshold Low

50 ppm

Lethal Concentration

LCLo (rat) = 5,816 ppm/4H

Explanatory Notes

Odor threshold from "Quick Guide: The Electronic NIOSH Pocket Guide to Chemical Hazards"; Flash point = 20 deg C;

Flammability (NFPA)

3: May ignite at ambient temperature

Adverse Effects
Methemoglobinemia

Methemoglobinemia, Primary

Links to Other NLM Databases
Health Studies

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Diseases

Occupational diseases associated with exposure to this agent: