Agent Name

1,2-Propanediol dinitrate

CAS Number

6423-43-4

Formula

C3-H6-N2-O6

Major Category

Nitrogen Compounds

Synonyms

PGDN; Propylene glycol-1,2-dinitrate; 1,2-Propylene glycol dinitrate; 1,2-Propanediol dinitrate; Isopropylene nitrate; Propylene dinitrate; Propylene glycol dinitrate; Propylene nitrate; [ChemIDplus]

Category

Nitrates and Nitrites

Description

Colorless liquid with a disagreeable odor. [Note: A solid below 18 degrees F.]; [NIOSH]

Sources/Uses

Used in Otto Fuel II, a torpedo propellant. [ACGIH]

Comments

Listed in the ACGIH table: "Examples of Industrial Chemicals for Which Methemoglobin Formation is NOT the Principal Cause of Toxicity"; Headache is a common symptom in new employees, but tolerance develops after repeated exposures. Volunteers exposed at 0.5 ppm for 6 to 8 hours showed impaired performance similar to the effects in these same subjects at blood alcohol concentrations of 100 to 150 mg/10 ml. Male volunteers exposed to levels from 0.03-1.5 ppm over a range of time showed no significant hematological effects. No evidence of chronic neurological effects was found in a group of 87 workers at a torpedo manufacturing plant where PGDN peak air concentrations measured from not detectable to 0.22 ppm (90% below 0.1 ppm). [ACGIH] An eye irritant; Can induce methemoglobinemia; [ICSC]

Exposure Assessment
BEI

Methemoglobin in blood = 1.5% of hemoglobin during or at end of shift. [ACGIH]

Skin Designation (ACGIH)

Yes

TLV (ACGIH)

0.05 ppm

MAK

0.05 ppm

Vapor Pressure

0.07 mm Hg

Lethal Concentration

LC50 (rat) > 1,350 mg/m3/4h

Adverse Effects
Methemoglobinemia

Methemoglobinemia, Secondary

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Health Studies

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