Agent Name

Propylene glycol monomethyl ether

Alternative Name

PGME

CAS Number

107-98-2

Formula

C4-H10-O2

Major Category

Solvents

Synonyms

1-Methoxy-2-hydroxypropane; 1-Methoxy-2-propanol; 2-Methoxy-1-methylethanol; 2-Propanol, 1-methoxy-; Closol; Dowanol 33B; Dowtherm 209; Methyl proxitol; PGME; Poly-Solve MPM; Propasol solvent M; Ucar Solvent LM (Obs.); [ChemIDplus] UN3092

Category

Glycol Ethers (P Series)

Description

Clear, colorless liquid with a mild, ethereal odor; [NIOSH]

Sources/Uses

Used as a solvent in paints, inks, nail polish removers, and cleaning agents; Also used in fininshing leather and in electronics and agriculture; [ACGIH] Used to make lacquers and paints, as a solvent for resins, celluloses, acrylics, dyes, and inks (gravure, flexographic and silk screening), as antifreeze, and in household cleaners and spot removers; [HSDB]

Comments

Rats inhaling 3000 ppm, 6 hours/day for 9 days, show signs of sedation, but tissue examination shows no evidence of gross or microscopic disease. Similarly exposed rats had increased liver weights after 6 months; Human volunteers exposed to 2500 ppm had severe lacrimation and painful breathing; In another human experiment, subjects complained of slight eye effects at 150 ppm, but not at 100 ppm; "TLV Basis" is eye and upper respiratory tract irritation; [ACGIH] A lachrymator; [CHEMINFO] A skin, eye, and respiratory tract irritant; Inhalation of high concentrations can cause CNS depression; [ICSC] See "Glycol ethers."

Exposure Assessment
Skin Designation (ACGIH)

Insufficient data

TLV (ACGIH)

50 ppm

STEL (ACGIH)

100 ppm

MAK

100 ppm

Vapor Pressure

12.5 mm Hg

Odor Threshold Low

10 ppm

Odor Threshold High

100 ppm

Lethal Concentration

LC50 (rat) = 10,000 ppm/5h

Explanatory Notes

Odor threshold from CHEMINFO, low (detection), high (objectionable); Flash point = 32 deg C;

Reference Link

ICSC: Propylene glycol monomethyl ether

Flammability (NFPA)

3: May ignite at ambient temperature

Adverse Effects
Lacrimator

Yes

Neurotoxin

CNS Solvent Syndrome

ACGIH Carcinogen

Not Classifiable

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Biomedical References

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure: