Agent Name

Monensin

CAS Number

17090-79-8

Formula

C36-H62-O11

Major Category

Biological Agents

Synonyms

A 3823A; ATCC 15413; Elancoban; Lilly 673140; Monelan; Monensic acid; Monensin A; Monensina [INN-Spanish]; Monensinum [INN-Latin]; 1,6-Dioxaspiro(4.5)decane-7-butyric acid, 2-(5-ethyltetrahydro-5-(tetrahydro-3-methyl-5-(tetrahydro-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyl-2H-pyran-2-yl)-2-furyl)-2-furyl)-9-hydroxy-beta-methoxy-alpha,gamma,2,8-tetramethyl-; [ChemIDplus]

Category

Bacterial Toxins

Description

Solid; [Merck Index]

Sources/Uses

Factor in antibiotic complex found in Streptomyces cinnamonensis; [Merck Index] Used as veterinary antibacterial and antifungal agent; as feed additive; as growth promoter in ruminants; as medicinal feed additive to treat coccidiosis in chickens and turkeys; [HSDB]

Comments

In human poisoning cases after ingestion, causes rhabdomyolysis, acute renal failure, and pulmonary edema. Target organs are the skeletal and cardiac muscles. [HSDB] Causes tremor and convulsions in lethal dose feeding studies of rats; Moderate eye irritant and mild skin irritant in rabbits; [RTECS] Adverse effects in chronic feeding studies of rats include skeletal and heart muscle damage, decreased leukocyte count, and weight gain. The acceptable daily intake (ADI) is 0-10 ug/kg; [JECFA]

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