Agent Name

Monocrotaline

CAS Number

315-22-0

Formula

C16-H23-N-O6

Major Category

Biological Agents

Synonyms

(13-alpha,14-alpha)-14,19-Dihydro-12,13-dihydroxy-20-norcrotalanan-11,15-dione; 12-beta,13-beta-Dihydroxy-12-alpha,13-alpha,14-alpha-trimethylcrotal-1-enine; 14,19-Dihydro-12,13-dihydroxy(13-alpha,14-alpha)-20-norcrotalanan-11,15-dione; 20-Norcrotalanan-11,15-dione, 14,19-dihydro-12,13-dihydroxy-, (13alpha,14alpha)-; A 6080; Crotaline; Monocrotalin; Retronecine cyclic 2,3-dihydroxy-2,3,4-trimethylglutarate; [ChemIDplus]

Category

Plant Toxins

Description

White solid; [Merck Index] Faintly beige powder; [MSDSonline]

Sources/Uses

Toxic pyrrolizidine alkaloid from Crotalaria spp; Used to induce lung diseases in rats; [Merck Index] Used in parts of Africa and India in traditional medicine; [HSDB]

Comments

"A pyrrolizidine alkaloid and a toxic plant constituent that poisons livestock and humans through the ingestion of contaminated grains and other foods. The alkaloid causes pulmonary artery hypertension, right ventricular hypertrophy, and pathological changes in the pulmonary vasculature. Significant attenuation of the cardiopulmonary changes are noted after oral magnesium treatment." [ChemIDplus] Emergency treatment: "Plants- pyrrolizidine alkaloids"; [HSDB] May cause irritation; Targets liver and lungs; Effects in high-dose animal studies include hepatocellular necrosis; [MSDSonline]

Adverse Effects
Hepatotoxin

Hepatotoxin, Secondary

IARC Carcinogen

Possible Carcinogen

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Other Information

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