Agent Name

Muscarine chloride

CAS Number

2303-35-7

Formula

C9-H20-N-O2.Cl

Major Category

Biological Agents

Synonyms

(+)-Muscarine chloride; 2-Furanmethanaminium, tetrahydro-4-hydroxy-N,N,N,5-tetramethyl-, chloride, (2S-(2alpha,4beta,5alpha))-; L-(+)-Muscarine chloride; [ChemIDplus]

Category

Mushroom Toxins

Description

Extremely hygroscopic solid; [Merck Index]

Sources/Uses

Muscarine: Alkaloid found in red variety of Amanita muscaria and other fungi; Used as a cholinergic drug; [Merck Index] Used strictly for research purposes; [HSDB]

Comments

Intravenous LD50 (mouse) = 230 ug/kg; [RTECS] Emergency treatment: "Mushrooms- muscarine/histamine"; Used in research because it causes excitatory effects on cells innervated by postganglionic cholinergic nerves, but none on nicotinic receptors of autonomic ganglia or skeletal muscles; [HSDB] Symptoms after ingestion are sweating, salivation, impaired vision, nausea, vomiting, abdominal pain, diarrhea, headache, and bronchospasm; High doses may cause lacrimation, incontinence, bradycardia, hypotension, and shock; [Merck Index] May cause irritation; Highly toxic by inhalation, skin absorption, and ingestion; Targets nerves; [MSDSonline]

Reference Link

INCHEM: Management of Poisoning by Unknown Fungi

Adverse Effects
Neurotoxin

Other CNS Neurotoxin

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Related Information in HazMap
Other Information

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