Agent Name

Muscimol

CAS Number

2763-96-4

Formula

C4-H6-N2-O2

Major Category

Biological Agents

Synonyms

3(2H)-Isoxazolone, 5-(aminomethyl)-; 3-Hydroxy-5-aminomethylisoxazole; 3-Isoxazolol, 5-(aminomethyl)-; 5-(Aminomethyl)-3(2H)-isoxazolone; 5-(Aminomethyl)-3-isoxazolol; 5-Aminomethyl-3-hydroxyisoxazole; 5-Aminomethyl-3-isoxyzole; Agarin; Agarine; Pantherin; Pantherine; [ChemIDplus]

Category

Mushroom Toxins

Description

Solid; [Merck Index] White powder; [MSDSonline]

Sources/Uses

Isolated from Amanita muscaria; Used to study GABA receptors; [Merck Index] Used in studies of GABA-A receptors; [ChemIDplus]

Comments

Causes somnolence and rigidity in rat experiments; In humans (route not reported), caused sleep, hallucinations, nausea, and vomiting; [RTECS] A strong CNS depressant; A GABA agonist; [Merck Index] May cause irritation and CNS depression; May cause neurotoxic effects and convulsions; [MSDSonline]

Reference Link

INCHEM: Management of Poisoning by Unknown Fungi

Exposure Assessment
Vapor Pressure

0.000294 mm Hg

Adverse Effects
Neurotoxin

Other CNS Neurotoxin

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

Search ChemIDplus

Related Information in HazMap
Other Information

No other related information on this agent was found.