Agent Name

N-Nitroso-N-methylurea

CAS Number

684-93-5

Formula

C2-H5-N3-O2

Major Category

Nitrogen Compounds

Synonyms

Methylnitrosourea; 1-Methyl-1-nitrosomocovina [Czech]; 1-Methyl-1-nitrosourea; 1-Nitroso-1-methylurea; Carbamide, N-methyl-N-nitroso-; MNU; Methylnitroso-harnstoff [German]; Methylnitrosouree [French]; N-Methyl-N-nitroso-harnstoff [German]; N-Methyl-N-nitrosourea; N-Nitroso-N-methyl-harnstoff [German]; N-Nitroso-N-methylcarbamide; NMH [German]; NMU; Nitrosomethylurea; O-Nitroso-N-methyl-harnstoff [German]; SKI 24464; SRI 859; Urea, N-methyl-N-nitroso-; [ChemIDplus]

Category

Nitrosamines

Description

Colorless or yellow solid; [HSDB]

Sources/Uses

Used as research chemical for its mutagenic effects on various plants; Formerly used to synthesize diazomethane in the laboratory; Not commercially produced in significant amounts; [HSDB]

Comments

Reported cause of allergic contact dermatitis; Mutagenic to human cells; Evidence of carcinogenicity in experimental animals; Teratogenic and embryotoxic; [HSDB] Sensitive to moisture and light; Decomposed slowly by water; A skin irritant; May cause skin rashes, leukopenia, and permanent eye injury; [CAMEO] Causes endocrine changes and decreased humoral immune response in intraperitoneal lethal-dose and toxic-dose studies of mice; Causes structural nerve changes in 6-day, intravenous study of rats; Causes changes in teeth in 16 week intermittent oral study of hamsters; [RTECS] May cause irritation; [Aldrich MSDS] See "NITROSAMINES."

Exposure Assessment
Vapor Pressure

0.02 mm Hg

Adverse Effects
IARC Carcinogen

Probable Carcinogen

NTP Carcinogen

Anticipated Human Carcinogen

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Related Information in HazMap
Other Information

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