Agent Name

N-Phenylhydroxylamine

CAS Number

100-65-2

Formula

C6-H7-N-O

Major Category

Nitrogen Compounds

Synonyms

Aniline, N-hydroxy-; Benzenamine, N-hydroxy-; Benzene, hydroxylamino-; Hydroxylamine, N-phenyl-; N-Hydroxyaniline; N-Hydroxybenzenamine; Phenylhydroxyamine; Phenylhydroxylamine; [ChemIDplus]

Category

Hydroxylamines

Description

Solid; [Merck Index] Tan to brown solid; [CAMEO]

Sources/Uses

Used as intermediate for cupferron and p-aminophenol; Not commercially produced in the US; [HSDB]

Comments

Occupational cases of severe poisoning have been reported; Markedly increases sister chromatid exchange in cultured human fibroblasts; Causes methemoglobinemia in rats and mice; Lethal-dosed rats did not exhibit methemoglobin levels sufficiently high to cause death by anoxia, suggesting that methemoglobinemia is not responsible for acute toxicity; Emergency treatment: Methemoglobinemia; [HSDB] An irritant; [CAMEO] Irritating to human skin; Causes hematuria and methemoglobinemia in subcutaneous, lethal-dose studies of rats and rabbits; Repeated dose studies of rats produce weight loss and changes to blood; [RTECS] May cause irritation; [Aldrich MSDS]

Exposure Assessment
Vapor Pressure

0.00795 mm Hg

Adverse Effects
Methemoglobinemia

Methemoglobinemia, Primary

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Diseases

Occupational diseases associated with exposure to this agent: