Agent Name

Nitrofen

CAS Number

1836-75-5

Formula

C12-H7-Cl2-N-O3

Major Category

Pesticides

Synonyms

2',4'-Dichloro-4-nitrobiphenyl ether; 2,4-Dechlorophenyl p-nitrophenyl ether; 2,4-Dichloro-1-(4-nitrophenoxy)benzene; 2,4-Dichloro-4'-nitrodiphenyl ether; 2,4-Dichloro-4'-nitrophenyl ether; 2,4-Dichlorophenyl 4-nitrophenyl ether; 2,4-Dichlorophenyl p-nitrophenyl ether; 2,4-Dichlorophenyl-p-nitro phenyl ether; 2,4-Dichlorphenyl-4-nitrophenylaether [German]; 4'-Nitro-2,4-dichlorodiphenyl ether; 4-(2,4-Dichlorophenoxy)nitrobenzene; 4-Nitro-2',4'-dichlorophenyl ether; Benzene, 2,4-dichloro-1-(4-nitrophenoxy)-; Ether, 2,4-dichlorophenyl p-nitrophenyl; FW 925; Mezotox; NIP; Niclofen; Nitrafen; Nitraphen; Nitrochlor; Nitrofene [ISO-French]; Nitrophen; Nitrophene; Preparation 125; TOK; TOK E; TOK E 40; TOK E-25; TOK WP-50; TOK-2; Tokkorn; Trizilin; Trizilin 25; [ChemIDplus]

Category

Herbicides, Protox-Inhibiting

Description

Colorless to brown solid; Darkens on light exposure; [ICSC] White, yellow, or dark brown solid; [HSDB] Yellow crystalline solid; [MSDSonline]

Sources/Uses

Used as pre- or post-emergence herbicide for control of annual broad-leaved and grass weeds in cereals, rice, sugar beets, ornamentals, vegetables, and public easements; No longer produced or marketed in the US; [HSDB]

Comments

A skin and respiratory tract irritant; May have effect on the CNS and liver and possibly carcinogenic to humans; "Animal tests show that this substance possibly causes malformations in human babies." [ICSC] Increase congenital malformations in rodent experiments at levels that were not overtly toxic to mothers; [REPROTOX] May cause skin irritation; [HSDB] May cause skin and eye irritation; [CAMEO] Caused convulsions and coma in a woman who ingest 10 ml/kg; [MSDSonline] See "Fluthiacet-methyl."

Restricted

Prohibited for use in the US, U.K., Federal Republic of Germany, Sweden, and the Russian Federation, and highly restricted in many other countries; [INCHEM] Banned in the EU; [eChemPortal: ESIS]

Exposure Assessment
Lethal Concentration

LCLo (cats) = 620 mg/m3/4h

Explanatory Notes

VP = 8.00E-6 mm Hg at 40 deg C; [ChemIDplus] Classified as 2B for "technical grade" substance; [IARC]

Adverse Effects
Neurotoxin

Other CNS Neurotoxin

Hepatotoxin

Hepatotoxin, Secondary

Reproductive Toxin

Yes

IARC Carcinogen

Possible Carcinogen

NTP Carcinogen

Anticipated Human Carcinogen

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

Search TOXNET

Chemical Information

Search ChemIDplus

Biomedical References

Search PubMed

Related Information in HazMap
Processes

Industrial Processes with risk of exposure: