Agent Name

Sulfuryl fluoride

CAS Number

2699-79-8

Formula

F2-O2-S

Major Category

Pesticides

Synonyms

Sulfur difluoride dioxide; Vikane; [NIOSH] UN2191

Category

Fumigants

Description

Colorless, odorless gas. [insecticide/fumigant] [Note: Shipped as a liquefied compressed gas.] [NIOSH]

Sources/Uses

Used as a structural fumigant to kill termites; [ACGIH]

Comments

Concentrations inside fumigated structures are as high as 4000 to 40,000 ppm. Inhalation exposure may cause pulmonary edema. [ACGIH] Because sulfuryl fluoride is heavier than air, workers who re-enter a treated area are at risk for fatal hypoxia. Muscle twitching and seizures have been reported after acute poisoning. [EPA Pesticides, p. 161] Possible frostbite from contact with liquid; [NIOSH] The exact toxic mechanism is not known, but increased fluoride ion concentrations have been found in poisoned victims. Systemic fluorosis may result from sulfuryl fluoride poisoning. Fluoride can cause hypocalcemia and hyperkalemia with secondary arrhythmias and central nervous effects including agitation, tetany, and seizures. [AHLS, p. 266-7] This gas has no warning properties, but cloropicrin is often added. After chronic inhalation studies, animals have evidence of liver injury. [HSDB] See "FLUORIDES."

Reference Link

EXTOXNET PIP - SULFURYL FLUORIDE

Exposure Assessment
Skin Designation (ACGIH)

Insufficient data

TIH

Yes

TLV (ACGIH)

5 ppm

STEL (ACGIH)

10 ppm

PEL (OSHA)

5 ppm

IDLH (NIOSH)

200 ppm

Excerpts from Documentation for IDLHs

Other animal data: It has been reported that less than 5% mortality resulted from exposure for 3 hours to 1,000 ppm [Taxay 1966].

Lethal Concentration

LC50 (rat) = 991 ppm/4H

Explanatory Notes

Not combustible; [CHEMINFO]

Reference Link

EPA Pesticide Chemical Search

Adverse Effects
Toxic Pneumonitis

Yes

Neurotoxin

Other CNS Neurotoxin

Hepatotoxin

Hepatotoxin, Secondary

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

Search TOXNET

Chemical Information

Search ChemIDplus

Biomedical References

Search PubMed

Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure: