Agent Name

o-Toluenesulfonamide

CAS Number

88-19-7

Formula

C7-H9-N-O2-S

Major Category

Nitrogen Compounds

Synonyms

2-Toluenesulfonamide; 2-Methylbenzenesulfonamide; 2-Tolylsulfonamide; Benzenesulfonamide, 2-methyl-; Toluene-2-sulfonamide; o-Methylbenzenesulfonamide; ortho-Toluenesulfonamide; ortho-Toluol-sulfonamid [German]; [ChemIDplus]

Category

Sulfonamides

Description

Colorless solid; [Hawley] White powder; [MSDSonline]

Sources/Uses

Used in mixtures with p-toluenesulfonamide as reactive plasticizer; Also used as a plasticizer for hot-melt adhesives and a chemical intermediate for fluorescent pigments and plasticizer resins; [HSDB] Used to make saccharin; [eChemPortal: SIDSUNEP] A contaminant of saccharin; [IARC]

Comments

A mutagen, tumorigen, reproductive effector, and moderate eye irritant; [RTECS] Used therapeutically, sulfonamides can cause a range of hypersensitivity reactions including rashes and injury to the liver and kidneys; Methemoglobinemia has been reported after overdose; [HSDB] An eye irritant; [ICSC] An irritant; [MSDSonline] See "p-Toluenesulfonamide" and "Toluenesulfonamide."

Reference Link

OECD SIDS: o-Toluenesulfonamide - 2002

Exposure Assessment
Vapor Pressure

6.0E-5 mm Hg

Adverse Effects
Hepatotoxin

Hepatotoxin, Secondary

Methemoglobinemia

Methemoglobinemia, Secondary

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Related Information in HazMap
Other Information

No other related information on this agent was found.