Agent Name

Ochratoxin A

CAS Number




Major Category

Biological Agents


(-)-N-((5-Chloro-8-hydroxy-3-methyl-1-oxo-7-isochromanyl)carbonyl)-3-phenylalanine; (R)-N-((5-Chloro-3,4-dihydro-8-hydroxy-3-methyl-1-oxo-1 H-2-benzopyran-7-yl)carbonyl)phenylalanine; Alanine, N-((5-chloro-8-hydroxy-3-methyl-1-oxo-7-isochromanyl)carbonyl)-3-phenyl-, (-)-; Antibiotic 9663; L-Phenylalanine, N-((5-chloro-3,4-dihydro-8-hydroxy-3-methyl-1-oxo-1H-2-benzopyran-7-yl)carbonyl)-, (R)-; N-(((3R)-5-Chloro-8-hydroxy-3-methyl-1-oxo-7-isochromanyl)carbonyl)-3-phenyl-L-alanine; Phenylalanine - ochratoxin A; [ChemIDplus] UN3462




Solid with a green fluorescence; [Merck Index] Faintly yellow powder; [MSDSonline]


Used as a research chemical; [HSDB] A toxic metabolite of Aspergillus ochraceus, Aspergillus sulphureus, Aspergillus melleus, and Penicillium viridicatum molds. Ochratoxins have been found as natural contaminants on corn, peanuts, storage grains, cottonseed, and other decaying vegetables; [Merck Index] Human exposure occurs primarily by ingestion of contaminated grain and pork products; [IARC] Produced by Penicillium verrucosum, a common contaminant of barley; [Reference #2]


May be fatal by ingestion or inhalation; [CAMEO] May cause irritation; Causes injury to the kidneys and liver in high-dose animal studies; [MSDSonline] Causes renal tubular injury and liver damage in high-dose animal studies; Oral LD50 = 0.2 mg/kg for dogs and 59 mg/kg for mice; High levels in the diet are associated with nephropathy in humans and swine in Balkan countries (Balkan nephropathy); [Hayes, p. 644] Factory workers handling contaminated coffee, cocoa beans, spices, and other foods have elevated ochratoxin serum levels; [Reference #1] MAC-2 (considered to be carcinogenic for man because sufficient data from long-term animal studies or limited evidence from animal studies substantiated by evidence from epidemiological studies indicate that it can make a significant contribution to cancer risk); [MAK]

Reference Link

External and internal dose in subjects occupational...[Int Arch Occup Environ Health. 2002] - PubMed Result

Exposure Assessment
Vapor Pressure

3.31E-16 mm Hg

Explanatory Notes

The Guide in the Emergency Response Guidebook is for "Toxins, extracted from living sources, solid, n.o.s."

Reference Link

PubMed Fulltext: Mycotoxins

Adverse Effects

Hepatotoxin, Secondary



IARC Carcinogen

Possible Carcinogen

NTP Carcinogen

Anticipated Human Carcinogen

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information


Chemical Information

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Biomedical References

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Related Information in HazMap
Other Information

No other related information on this agent was found.