Agent Name

Oleandrin

CAS Number

465-16-7

Formula

C32-H48-O9

Major Category

Biological Agents

Synonyms

16beta-(Acetyloxy)-3beta-((2,6-dideoxy-3-O-methyl-L-arabino-hexopyranosyl)oxy)-14-hydroxycard-20-(22)-enolide; Card-20(22)-enolide, 16-(acetyloxy)-3-((2,6-dideoxy-3-O-methyl-alpha-L-arabino-hexopyranosyl)oxy)-14-hydroxy-, (3beta,5beta,16beta)-; Corrigen; Foliandrin; Folinerin; Neriol; Neriolin; Neriostene; Oleandrina [Spanish]; Oleandrine; [ChemIDplus]

Category

Plant Toxins

Description

Solid; [Merck Index] Colorless odorless solid; [IARC]

Sources/Uses

Found in Nerium oleander L., Apocynaceae (Laurier rose); Used as a cardiotonic and diuretic; [Merck Index] Oleander is used as rat poison; [HSDB] Active principle of the oleander plant used formerly in rodenticides and insecticides; Used currently in pharmaceutical products; [IARC]

Comments

A glycoside toxin; [IARC] Emergency treatment: "Plants- cardiac glycosides"; Overdose of digitalis and other cardiac glycosides causes heart irritability, dysrhythmias, bradycardia, heart block, and hyperkalemia. [HSDB] Ingestion of just a few leaves of oleander may cause cardiac toxicity; [Olson, p. 195]

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