Agent Name

1,1,1,2-Tetrachloro-2,2-difluoroethane

CAS Number

76-11-9

Formula

C2-Cl4-F2

Major Category

Solvents

Synonyms

1,1-Difluoro-1,2,2,2-tetrachloroethane; 1,1-Difluoroperchloroethane; 2,2-Difluoro-1,1,1,2-tetrachloroethane; 2,2-Difluorotetrachloroethane; CFC 112a; Ethane, 1,1-difluoro-1,2,2,2-tetrachloro-; F 112a; Fluorocarbon 112a; Halocarbon 112a; R 112a; Refrigerant 112a; [ChemIDplus]

Category

Chlorofluorocarbons

Description

Colorless solid with a slight, ether-like odor. [Note: A liquid above 105 degrees F]; [NIOSH]

Sources/Uses

CFC-112a has been used as a refrigerant. [ACGIH] "Use in dry cleaning industry; in polymer & plastics industry as blowing or foaming agent; as solvent extractor for separation & purification of biological material; as a dye solvent to give brighter colors and to detect surface cracks or defects in metals; as a corrosion inhibitor."; [HSDB]

Comments

Rats exposed to 10,000 ppm for 2 hours show signs of intoxication. At 20,000 to 30,000 ppm, all rats die within 1.5 to 2 hours. There are signs of kidney and liver injury, but no signs of pulmonary injury. [ACGIH] See "CHLOROFLUOROCARBONS";

Restricted

See CHLOROFLUOROCARBONS

Exposure Assessment
Skin Designation (ACGIH)

Insufficient data

TLV (ACGIH)

100 ppm

PEL (OSHA)

500 ppm

MAK

200 ppm

IDLH (NIOSH)

2000 ppm

Excerpts from Documentation for IDLHs

Other animal data: Rats exposed to 10,000 ppm for 1.5 to 2 hours showed slight signs of intoxication but no loss of reflexes, while a concentration of 20,000 to 30,000 ppm was fatal in 1.0 to 2.5 hours [Greenberg and Lester 1950].

Vapor Pressure

60 mm Hg

Lethal Concentration

LCLo (rat) = 20,000 ppm/30 min

Adverse Effects
Neurotoxin

CNS Solvent Syndrome

Hepatotoxin

Hepatotoxin, Secondary

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent: