Agent Name

1,1,2,2-Tetrachloro-1,2-difluoroethane

CAS Number

76-12-0

Formula

C2-Cl4-F2

Major Category

Solvents

Synonyms

1,2-Difluoro-1,1,2,2-tetrachloroethane; CFC-112; Daiflon 112; Daiflon S2; F-112; FC 112; Fluorocarbon 112; Freon 112; Freon R 112; Genetron 112; Halocarbon 112; R 112; Refrigerant 112; Tetrachloro-1,2-difluoroethane; Ucon 112; sym-Tetrachlorodifluoroethane; [ChemIDplus]

Category

Chlorofluorocarbons

Description

Colorless solid or liquid (above 77 degrees F) with a slight, ether-like odor; [NIOSH]

Sources/Uses

CFC-112 has been used mainly as a refrigerant. [ACGIH]

Comments

Rats exposed to 10,000 ppm for 2 hours show signs of intoxication. Exposure to 20,000 to 30,000 ppm for 1 to 2.5 hours causes fatal pulmonary hemorrhages. It is concluded that CFC-112 at concentrations of 1% (10,000 ppm) or more is a pulmonary irritant. [ACGIH] See "CHLOROFLUOROCARBONS"

Restricted

See CHLOROFLUOROCARBONS

Exposure Assessment
Skin Designation (ACGIH)

Insufficient data

TLV (ACGIH)

50 ppm

PEL (OSHA)

500 ppm

MAK

200 ppm

IDLH (NIOSH)

2000 ppm

Excerpts from Documentation for IDLHs

Other animal data: Rats exposed to 10,000 ppm for 1.5 to 2 hours showed slight signs of intoxication but no loss of reflexes, while 20,000 to 30,000 ppm was fatal in 1.0 to 2.5 hours [Greenberg and Lester 1950].

Vapor Pressure

50.5 mm Hg

Lethal Concentration

LC50 (rat) = 20,000 ppm/15 min

Explanatory Notes

mp = 26 deg C; bp = 92.8 deg C; Thermal decomposition products include HCl, HF, and phosgene; [ACGIH]

Adverse Effects
Toxic Pneumonitis

Yes

Neurotoxin

CNS Solvent Syndrome

Hepatotoxin

Hepatotoxin, Secondary

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

Search TOXNET

Chemical Information

Search ChemIDplus

Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent: