Agent Name

N,N-Dimethyl-N-dodecylamine oxide

Alternative Name

Lauramine oxide

CAS Number

1643-20-5

Formula

C14-H31-N-O

Major Category

Other Uses

Synonyms

Lauramine oxide; Lauryl dimethyl amine oxide; N,N-Dimethyl-1-dodecanamine-N-oxide; 1-Dodecanamine, N,N-dimethyl-, N-oxide; Ammonyx AO; Ammonyx LO; Amonyx AO; Aromox DMCD; Aromox dmmc-W; Conco XAL; DDNO; Dimethylaurylamine oxide; Dimethyldodecylamine N-oxide; Dimethyldodecylamine oxide; Dimethyllaurylamine oxide; Dodecylamine, N,N-dimethyl-, N-oxide; Dodecyldimethylamine N-oxide; Dodecyldimethylamine oxide; Empigen OB; Lauryldimethylamine N-oxide; Lauryldimethylamine oxide; N,N-Dimethyl-dodecylaminoxid [Czech]; N,N-Dimethyldodecylamine oxide; N-Lauryl-N,N-dimethylamine oxide; N-Lauryldimethylamine N-oxide; Oxyde de dimethyllaurylamine [French]; Refan [Russian]; n-Dodecyldimethylamine oxide; [ChemIDplus] UN3259

Category

Emulsifiers/Surfactants

Description

Highly hygroscopic solid; [HSDB]

Sources/Uses

Used as a foam builder and stabilizer; Used in cosmetics, emollients, conditioners, emulsifiers, dishwasher detergents, shampoos, soaps, and antistatic, wetting, antibacterial, and antifungal agents; [HSDB]

Comments

Caused severe skin irritation (including severe erythema and edema, fissuring with bleeding, and necrosis) in rabbit studies; High dose animal feeding studies produced no significant adverse effects; [HSDB] Amine oxides are metabolized and rapidly excreted after ingestion; Effects on skin are: 1% solutions not irritating, 5% solutions moderately irritating, and 30% solutions severely irritating; No evidence of skin sensitization; No evidence of carcinogenic response or reproductive toxicity; [OECD SIDS] A corrosive substance that can cause injury to the skin, eyes, and respiratory tract; Inhalation may cause chemical pneumonitis; [MSDSonline]

Exposure Assessment
Vapor Pressure

6.23E-8 mm Hg

Lethal Concentration

LC50 (rat) = 5.3 g/mL/4h (aerosol of 0.3% lauramine oxide;

Explanatory Notes

The Guide in the Emergency Response Guidebook is for "Amines, solid, corrosive, n.o.s."

Adverse Effects
Toxic Pneumonitis

Yes

Dermatotoxin

Skin Burns

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Related Information in HazMap
Processes

Industrial Processes with risk of exposure: