Agent Name

1,2-Epoxybutane

Alternative Name

1,2-Butylene oxide

CAS Number

106-88-7

Formula

C4-H8-O

Major Category

Plastics & Rubber

Synonyms

1,2-Butylene oxide; ( -)-Ethyloxirane; (+-)-2-Ethyloxirane; 1,2-Butene oxide; 1,2-Butene oxide (VAN); 1,2-Monoepoxybutane; 1-Butylene oxide; 2-Ethyloxirane; Butane, 1,2-epoxy-; DL-1,2-Epoxybutane; Ethyl ethylene oxide; Ethylene oxide, ethyl-; Ethylethylene oxide; Ethyloxirane; Oxirane, ethyl-; alpha-Butylene oxide; n-Butene-1,2-oxide; [ChemIDplus] UN3022

Category

Epoxides

Description

Colorless liquid with a characteristic odor; [ICSC] Colorless liquid with an unpleasant odor; May decompose on exposure to moisture; [MSDSonline]

Sources/Uses

Used to make polymers; Also used as a stabilizer and acid scavenger for chlorinated solvents and a corrosion inhibitor; [HSDB]

Comments

A skin, eye, and respiratory tract irritant; Inhalation of high concentrations can cause CNS depression; [ICSC] Danger of cutaneous absorption; [MAK] Toxic by inhalation at room temperature; [Hawley] Liquid or vapor can burn eyes; May cause skin sensitization; [CAMEO] A corrosive substance that can cause injury to the skin, eyes, and respiratory tract; Inhalation may cause chemical pneumonitis and pulmonary edema; [MSDSonline] No data available on human exposure to the pure substance; [AIHA] 1,2-Butylene oxide, stabilized (UN3022) has warning of explosive polymerization; [ERG 2016] See "Ethylene oxide."

Exposure Assessment
WEEL

2 ppm

Vapor Pressure

180 mm Hg

Odor Threshold Low

0.07 ppm

Odor Threshold High

0.71 ppm

Lethal Concentration

LC50 (rat) = 6,300 mg/m3/4h

Explosive Polymerization

Yes

Explanatory Notes

Flash point = -22 deg C; [ICSC] Odor threshold low (absolute perception limit), and high (recognition) from CHEMINFO; The Guide from the Emergency Response Guidebook is for "1,2-Butylene oxide, stabilized."

Adverse Effects
Toxic Pneumonitis

Yes

Neurotoxin

Other CNS Neurotoxin

Dermatotoxin

Skin Burns

IARC Carcinogen

Possible Carcinogen

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Biomedical References

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent: