Agent Name

Oxydemeton-methyl

CAS Number

301-12-2

Formula

C6-H15-O4-P-S2

Major Category

Pesticides

Synonyms

Aimco systox; Demeton-S methyl sulfoxide; Demeton-S-methyl sulfoxid [German]; Demeton-S-methyl sulfoxide; Demeton-S-methyl-sulfoxid [German]; Demeton-methyl sulphoxide; Dimethyl S-(2-eththionylethyl) thiophosphate; ENT 24,964; Ethanethiol, 2-(ethylsulfinyl)-, S-ester with O,O-dimethyl phosphorothioate; Isomethylsystox sulfoxide; Metaisosystox sulfoxide; Metaisosystoxsulfoxide; Metasystemox; Metasystemox R; Metasystox-R; Metasytox R; Methyl oxydemeton S; Metilmercaptofosoksid (USSR); O,O-Dimethyl S-(2-(ethylsufinyl)ethyl) thiophosphate; O,O-Dimethyl S-(2-(ethylsulfinyl)ethyl) monothiophosphate; O,O-Dimethyl S-(2-(ethylsulfinyl)ethyl) phosphorothioate; O,O-Dimethyl S-(2-eththionylethyl) phosphorothioate; O,O-Dimethyl S-(2-ethylsulfinyl)ethyl thiophosphate; O,O-Dimethyl S-ethylsulphinylethyl phosphorothiolate; O,O-Dimethyl-S-(2-aethylsulfinyl-aethyl)-thiolphosphat [German]; O,O-Dimethyl-S-(2-ethylsulfinyl-ethyl)-monothiofosfaat [Dutch]; O,O-Dimethyl-S-(3-oxo-3-thia-pentyl)-monothiophosphat [German]; O,O-Dimetil-S-(2-etil-solfinil-etil)-monotiofosfato [Italian]; Oxydemeton-methyl; Oxydemeton-metile [Italian]; Oxydemetonmethyl; Phosphorothioic acid, O,O-dimethyl S-(2-(ethylsulfinyl)ethyl) ester; Phosphorothioic acid, S-(2-(ethylsulfinyl)ethyl) O,O-dimethyl ester; R 2170; S-(2-(Ethylsulfinyl)ethyl) O,O-dimethl phosphorothioate; S-(2-(Ethylsulfinyl)ethyl) O,O-dimethyl phosphorothioate; S-2-Ethylsulphinylethyl O,O-dimethyl phosphorothioate; Thiophosphate de O,O-dimethyle et de S-2-ethylsulfinylethyle [French]; S-(2-(Ethylsulfinyl)ethyl) O,O-dimethyl ester phosphorothioic acid; [ChemIDplus] UN2784

Category

Organophosphate Insecticides

Description

Colorless or yellow liquid; [HSDB] Clear amber liquid; [CAMEO]

Sources/Uses

Used as systemic insecticide and acaricide for cotton, vegetables, fruits, and field crops; [HSDB]

Comments

A cholinesterase inhibitor; Can be absorbed through skin; [CAMEO] A woman who was five months pregnant attempted suicide by ingestion and was hospitalized with symptoms including miosis, respiratory distress, muscular fasciculations, and coma (12 hours after admittance); Blood cholinesterase was reduced by 90%; The remainder of her pregnancy was without incident, and the babys neurological exams at birth and 8 days later were normal; [HSDB] Occupational exposure less likely to be symptomatic or require hospitalization than exposure to other cholinesterase inhibitors; [Reference #1] The average of two baseline respective cholinesterase activity determinations three days apart, with no exposures to enzyme inhibiting pesticides for at least 30 days, is recommended for each worker prior to exposure to cholinesterase inhibitors because of large inter-individual differences in published baseline values. To be established at least once a year. Removal from workplace exposures is recommended until the cholinesterase activity returns to within 20% of baseline. [TLVs and BEIs]

Restricted

Banned in the EU for use as pesticide for plant protection; [eChemPortal: ESIS] Restricted use pesticide (RUP); [Reference #1]

Reference Link

EPA Pesticide Chemical Search

Exposure Assessment
BEI

Acetylcholinesterase activity in red blood cells = 70% of individual's baseline; Butylcholinesterase activity in serum or plasma = 60% of individual's baseline; Sample at end of shift; [TLVs and BEIs]

Vapor Pressure

2.85E-5 mm Hg

Lethal Concentration

LC50 (rat) = 427 mg/m3/1h

Explanatory Notes

The Guide in the Emergency Response Guidebook is for "Organophosphorus pesticide, liquid, flammable, toxic."

Reference Link

INCHEM JMPR: Oxydemeton-methyl - 2002

Adverse Effects
Other Poison

Organophosphate

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Biomedical References

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure: