Agent Name

4-Chloroacetophenone

CAS Number

99-91-2

Formula

C8-H7-Cl-O

Major Category

Other Classes

Synonyms

1-(4-Chlorophenyl)ethanone; 4'-Chloroacetophenone; 4-Acetylchlorobenzene; 4-Chlorophenyl methyl ketone; Acetophenone, 4'-chloro-; Ethanone, 1-(4-chlorophenyl)-; Methyl 4-chlorophenyl ketone; Methyl p-chlorophenyl ketone; p-Acetylchlorobenzene; p-Chloracetophenone; p-Chloroacetophenone; p-Chlorophenyl methyl ketone; [ChemIDplus] UN1697

Category

Aromatic Ketones, Halogenated

Description

Liquid; [Merck Index] Colorless liquid; [MSDSonline]

Sources/Uses

Used as a chemical intermediate for pharmaceuticals; [HSDB]

Comments

"Highly irritating to eyes"; [Merck Index] May cause allergic contact dermatitis; [HSDB] An irritant; Effects in high-dose animal studies include lacrimation and acute pulmonary edema; [MSDSonline] See "alpha-Chloroacetophenone."

Exposure Assessment
Vapor Pressure

0.12 mm Hg

Lethal Concentration

LC50 (mice) = 1,752 mg/m3/15min

Explanatory Notes

The Guide in the Emergency Response Guidebook is for "Chloroacetophenone, liquid."

Adverse Effects
Skin Sensitizer

Yes

Toxic Pneumonitis

Yes

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

Search TOXNET

Chemical Information

Search ChemIDplus

Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent: