Agent Name

N,N'-Diphenyl-p-phenylenediamine

CAS Number

74-31-7

Formula

C18-H16-N2

Major Category

Nitrogen Compounds

Synonyms

N,N'-Diphenyl-4-phenylenediamine; p-Phenylenediamine, N,N'-diphenyl-; 1,4-Benzenediamine, N,N'-diphenyl-; 1,4-Bis(phenylamino)benzene; 1,4-Dianilinobenzene; 4,4'-Diphenyl-p-phenylenediamine; 4-Phenylaminodiphenylamine; AgeRite DPPD; Altofane DIP; Antage DP; Antigene P; Antioxidant H; DFFD; DPPD; Diafen FF; Diphenyl-p-phenylenediamine; Ekaland DPPD; Flexamine G; JZF; N,N'-Difenyl-p-fenylendiamin [Czech]; N,N'-Diphenyl-1,4-phenylenediamine; N,N-Diphenyl-1,4-benzenediamine; Naugard J; Nocrac DP; Nonflex H; Nonox DPPD; Permanax 18; Permanax DPPD; Stabilizer DPPD; p-Bis(phenylamino)benzene; p-Phenylaminodiphenylamine; [ChemIDplus]

Category

Amines, Polyaromatic

Description

Colorless solid; Commercial product is greenish-brown solid; [Merck Index] Colorless, grey, or white solid; [HSDB] Powder; [MSDSonline]

Sources/Uses

Used as antioxidant (rubber, polyethylene, feedstuffs, petroleum, vegetable oils, animal fats, and oils), polymerization inhibitor, copper degradation inhibitor, and as an intermediate (dyes, drugs, plastics, and detergents); [HSDB]

Comments

May cause skin sensitization; [ICSC] Danger of skin sensitization; [MAK] Food concentrations as low as 0.005% increase frequency of stillbirths in pregnant rats; Emergency treatment: "Paraphenylenediamine"; In sensitized individuals, paraphenylenediamine may cause allergic contact dermatitis following application as a hair dye and asthma following inhalation; Following ingestion, can cause angioneurotic edema, methemoglobinemia, acute tubular necrosis, and hepatotoxicity; An adult died after ingestion of 3 grams of p-phenylenediamine; Another adult who ingested 1800 mg developed angioneurotic edema and acute renal failure; [HSDB] May cause skin sensitization; [eChemPortal: ESIS] A mild eye irritant; Causes changes in liver weight, renal tubules, and clotting factors in repeated feeding studies of rats; [RTECS] See "p-Phenylenediamine."

Exposure Assessment
Vapor Pressure

6.35E-9 mm Hg

Adverse Effects
Skin Sensitizer

Yes

Hepatotoxin

Hepatotoxin, Secondary

Methemoglobinemia

Methemoglobinemia, Secondary

Links to Other NLM Databases
Health Studies

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Toxicity Information

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Chemical Information

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Biomedical References

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure: