Agent Name

p-Toluenesulfonamide

CAS Number

70-55-3

Formula

C7-H9-N-O2-S

Major Category

Nitrogen Compounds

Synonyms

4-Methylbenzenesulfonamide; 4-Toluenesulfanamide; 4-Toluenesulfonic acid, amide; Benzenesulfonamide, 4-methyl-; Toluene-4-sulfonamide; Toluene-p-sulphonamide; Tolylsulfonamide; Tosylamide; p-Methylbenzenesulfonamide; p-Toluenesulfamide; p-Toluenesulfonylamide; p-Tolylsulfonamide; p-Tosylamide; para-Toluenesulfonamide; [ChemIDplus]

Category

Sulfonamides

Description

White solid; [Hawley] White powder; [MSDSonline]

Sources/Uses

Used to retard growth of fungi and mildew in paints, plasticizers, and resins; Also used as a plasticizer for hot-melt adhesives (commonly found in commercial mixtures with o-isomer); [HSDB] Used as intermediate for pesticides; [eChemPortal: SIDSUNEP]

Comments

Used therapeutically, sulfonamides can cause a range of hypersensitivity reactions including rashes and injury to the liver and kidneys; Methemoglobinemia has been reported after sulfonamide poisoning; [HSDB] An eye irritant; [ICSC] Causes somnolence and weakness in subcutaneous lethal-dose studies of guinea pigs; [RTECS] An irritant; [MSDSonline]

Reference Link

OECD SIDS: p-Toluenesulfonamide

Exposure Assessment
Vapor Pressure

9.6E-5 mm Hg

Adverse Effects
Hepatotoxin

Hepatotoxin, Secondary

Methemoglobinemia

Methemoglobinemia, Secondary

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

Search ChemIDplus

Related Information in HazMap
Processes

Industrial Processes with risk of exposure: