Agent Name

m-Toluidine

CAS Number

108-44-1

Formula

C7-H9-N

Major Category

Nitrogen Compounds

Synonyms

1-Amino-3-methylbenzene; 3-Amino-1-methylbenzene; 3-Aminophenylmethane; 3-Aminotoluen [Czech]; 3-Aminotoluene; 3-Methylaniline; 3-Methylbenzenamine; 3-Toluidine; Aniline, 3-methyl-; m-Aminotoluene; m-Methylaniline; m-Methylbenzenamine; m-Toluidin [Czech]; m-Toluidine; m-Toluidyna [Polish]; m-Tolylamine; [ChemIDplus] UN1708; UN1993

Category

Amines, Aromatic

Description

Colorless to light-yellow liquid with an aromatic, amine-like odor; [Note: Used as a basis for many dyes.]; [NIOSH]

Sources/Uses

Used in the production of dyes and other chemicals; [ACGIH]

Comments

The toxicity of m-toluidine is similar to that of o-toluidine. Given intravenously to cats, a dose of 27 mg/kg induces 60% methemoglobinemia. Methemoglobinemia and anemia have been reported after occupational exposure. Listed in the table "Examples of Industrial Chemicals for Which Methemoglobin Formation is NOT the Principal Cause of Toxicity"; [ACGIH] Solid form causes first degree burns on short exposure; [CHRIS] A skin and eye irritant; Can induce methemoglobinemia; [ICSC]

Exposure Assessment
BEI

Methemoglobin in blood = 1.5% of hemoglobin during or at end of shift. [ACGIH]

Skin Designation (ACGIH)

Yes

TLV (ACGIH)

2 ppm

Vapor Pressure

0.3 mm Hg

Odor Threshold Low

0.46 ppm

Odor Threshold High

5.9 ppm

Explanatory Notes

Flash point = 187 deg F; Odor threshold values from American Industrial Hygiene Association;

Adverse Effects
Methemoglobinemia

Methemoglobinemia, Secondary

Dermatotoxin

Skin Burns

ACGIH Carcinogen

Not Classifiable

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Biomedical References

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Related Information in HazMap
Activities

Activities with risk of exposure: