Agent Name

Tributyl phosphate

CAS Number

126-73-8

Formula

C12-H27-O4-P

Major Category

Other Classes

Synonyms

Butyl phosphate; Butyl phosphate, ((BuO)3PO); Butyl phosphate, tri-; Celluphos 4; Disflamoll TB; MCS 2495; Phosphoric acid, tributyl ester; TBP; Tri-N-butylphosphate; Tri-n-butyl phosphate; Tributilfosfato [Italian]; Tributoxyphosphine oxide; Tributyl phosphate; Tributyle (phosphate de) [French]; Tributylfosfaat [Dutch]; Tributylfosfat [Czech]; Tributylphosphat [German]; Tributylphosphate; [ChemIDplus]

Category

Organophosphates, Other

Description

Colorless to pale-yellow, odorless liquid; [NIOSH]

Sources/Uses

Mainly used as a flame retardant in aircraft hydraulic fluid, which can contain 25 to 75% TBP; Also used as a solvent (rare earth extraction and nuclear fuel cycle), plasticizer, carrier for fluorescent dyes, and antifoam agent (cement casings for oil wells); [ACGIH] Used as an antifoaming agent (concrete, textile, and paper industries); [HSDB]

Comments

"TLV Basis" is bladder, eye, and upper respiratory tract irritation; Animals given repeated oral doses show necrosis, hyperplasia, and subsequent neoplasia of the urinary bladder epithelium with a NOEL of 9-12 mg/kg/day equivalent to a worker exposed by inhalation to 63-84 mg/m3; In lethal dose studies, animals have mild anesthesia, pronounced weakness, and respiratory failure; In inhalation studies, serum cholinesterase activity is depressed on the day after exposure; No evidence of nerve damage (OPIDN) in standard protocols testing chickens; [ACGIH] If left on clothing, can cause reddening of skin; [CHRIS] Irritating to the skin, eyes, and respiratory tract; [ICSC]

Exposure Assessment
BEI

Cholinesterase activity in red blood cells = 70% of individual's baseline sampling time discretionary

Skin Designation (ACGIH)

Insufficient data

TLV (ACGIH)

5 mg/m3, inhalable fraction and vapor

PEL (OSHA)

5 mg/m3

MAK

11 mg/m3

IDLH (NIOSH)

327 mg/m3

Excerpts from Documentation for IDLHs

"Human data: Nausea and headache have been reported in workers exposed to 15 mg/m3 (1.4 ppm) [Mastromatteo 1964]." [NIOSH]

Vapor Pressure

0.00113 mm Hg

Lethal Concentration

LC50 (rat) = 28,000 mg/m3/1H

Explanatory Notes

Flash point = 146 deg C;

Flammability (NFPA)

1: Must be preheated

Adverse Effects
ACGIH Carcinogen

Confirmed Animal

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

Search TOXNET

Chemical Information

Search ChemIDplus

Related Information in HazMap
Processes

Industrial Processes with risk of exposure: