Agent Name

Trichloroacetic acid

CAS Number

76-03-9

Formula

C2-H-Cl3-O2

Major Category

Other Classes

Synonyms

Acetic acid, trichloro-; Acetic acid, trichloro- (solid); Aceto-caustin; Acide trichloracetique [French]; Acido tricloroacetico [Italian]; Amchem grass killer; Konesta; Kyselina trichloroctova [Czech]; TCA; Tecane; Trichloorazijnzuur [Dutch]; Trichloracetic acid; Trichloressigsaeure [German]; Trichloroacetate; Trichloroacetic acid; Trichloroacetic acid (IUPAC); Trichloroethanoic acid; Trichloromethanecarboxylic acid; [ChemIDplus] UN1839; UN2564

Category

Organic Acids

Description

Colorless to white, crystalline solid with a sharp, pungent odor; [NIOSH] Deliquescent; [CHEMINFO]

Sources/Uses

Used as a medication (peeling agent to remove wrinkles) and in organic synthesis; Generated in chlorinated water that contains organic matter; The sodium salt of TCA is used as a pre- and post-emergent herbicide; [ACGIH]

Comments

May cause skin burns; [NIOSH] Highly corrosive to skin; [Quick CPC] A skin, eye, and respiratory tract irritant; A corrosive substance that can cause pulmonary edema; [ICSC] TLV is based on the potential to cause eye and respiratory tract irritation; Evidence of kidney and liver injury in high-dose animal studies; Mice with lifetime exposures to TCA in drinking water develop hepatic carcinomas (NOEL = 6 to 8 mg/kg); Not carcinogenic in rats; Oral LD50 (rats) = 3.32 g/kg; [ACGIH]

Exposure Assessment
Skin Designation (ACGIH)

Insufficient data

TLV (ACGIH)

0.5 ppm

MAK

0.2 ppm

Vapor Pressure

0.06 mm Hg

Odor Threshold Low

0.24 ppm

Odor Threshold High

0.37 ppm

Explanatory Notes

Recognition odor threshold from CHEMINFO;

Adverse Effects
Toxic Pneumonitis

Yes

Dermatotoxin

Skin Burns

IARC Carcinogen

Possible Carcinogen

ACGIH Carcinogen

Confirmed Animal

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Biomedical References

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Related Information in HazMap
Other Information

No other related information on this agent was found.