Agent Name

Phalloidin

CAS Number

17466-45-4

Formula

C35-H48-N8-O11-S

Major Category

Biological Agents

Synonyms

Cyclic(L-alanyl-D-threonyl-L-cysteinyl-cis-4-hydroxy-L-prolyl-L-alanyl-2-mercapto-L-tryptophyl-4,5-dihydroxy-L-leucyl), cyclic (3,6)-sulfide; Phalloidine; [ChemIDplus] UN3462

Category

Mushroom Toxins

Description

White solid; [MSDSonline]

Sources/Uses

A toxin from the poisonous green fungus Amanita phalloides; [Merck Index] Used for physiological studies; [HSDB]

Comments

10 to 20 times less toxic than alpha-amanitin, but faster acting; [Merck Index] Intraperitoneal LD50 (mouse) = 2 mg/kg; [RTECS] "Very toxic polypeptide isolated mainly from AMANITA phalloides (Agaricaceae) or death cup; causes fatal liver, kidney and CNS damage in mushroom poisoning; used in the study of liver damage." [ChemIDplus] Emergency treatment: "Mushrooms- cyclopeptides"; [HSDB] May cause irritation; May be fatal by inhalation, skin absorption, and ingestion; Targets the kidneys and liver; Unlike amanitin poisoning, which may be delayed for 12 to 24 hours, phalloidin can be fatal in 1 to 2 hours; [Aldrich MSDS] See "alpha-Amanitin."

Reference Link

INCHEM: Management of Poisoning by Unknown Fungi

Exposure Assessment
Explanatory Notes

The Guide in the Emergency Response Guidebook is for "Toxins, extracted from living sources, solid, n.o.s."

Adverse Effects
Neurotoxin

Other CNS Neurotoxin

Hepatotoxin

Hepatotoxin, Secondary

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Related Information in HazMap
Other Information

No other related information on this agent was found.