Agent Name

1,1,2-Trichloro-1,2,2-trifluoroethane

CAS Number

76-13-1

Formula

C2-Cl3-F3

Major Category

Solvents

Synonyms

1,1,2-Trichlorotrifluoroethane; 1,1,2-Trifluoro-1,2,2-trichloroethane; 1,1,2-Trifluorotrichloroethane; 1,2,2-Trichlorotrifluoroethane; Arcton 63; Arklone P; Asahifron 113; CFC-113; Chlorofluorocarbon 113; Daiflon S 3; Ethane, 1,1,2-trichloro-1,2,2-trifluoro-; F 113; FC 113; Flugene 113; Fluorocarbon 113; Forane 113; Freon 113; Freon 113TR-T; Freon F113; Freon R 113; Freon TF; Frigen 113; Frigen 113 TR-T; Frigen 113A; Frigen 113TR; Frigen 113TR-N; Frigen 113tr-T; Genesolv D; Genetron 113; Halocarbon 113; Isceon 113; Kaiser chemicals 11; Kaltron 113MDR; Khladon 113; Ledon 113; Propellant 113; R 113; R 113 (Halocarbon); Racon 113; Refrigerant 113; Refrigerant R 113; Trichlorotrifluoroethane; Ucon fluorocarbon 113; [ChemIDplus]

Category

Chlorofluorocarbons

Description

Colorless to water-white liquid with an odor like carbon tetrachloride at high concentrations. [Note: A gas above 118 degrees F.]; [NIOSH]

Sources/Uses

CFC-113 has been used as s solvent (degreasing and dry cleaning), refrigerant, heat transfer liquid, and chemical intermediate; [ACGIH]

Comments

A weak narcotic and strong cardiac sensitizer compared to other CFCs; In animal experiments, CNS depression occurs with exposures above 12,000 ppm; Mild liver changes are noted at concentrations somewhat below this; [ACGIH] Inhalation of high concentrations can cause CNS depression and cardiac arrhythmias; In confined space spill, may displace air and act as simple asphyxiant; An eye irritant; [ICSC]

Restricted

See CHLOROFLUOROCARBONS

Exposure Assessment
Skin Designation (ACGIH)

Insufficient data

TLV (ACGIH)

1000 ppm

STEL (ACGIH)

1250 ppm

PEL (OSHA)

1000 ppm

MAK

500 ppm

IDLH (NIOSH)

2000 ppm

Excerpts from Documentation for IDLHs

Human data: Human volunteers exposed to 2,500 ppm had subjective symptoms of diminished concentration, somnolence, and head heaviness within 30 minutes of initiation of exposure and slight but definite further significant decrements at exposures for 2.75 hours at 4,500 ppm [Stopps and McLaughlin 1967]. No adverse changes were noted in volunteers exposed to 500 or 1,000 ppm for 6 hours per day, 5 days per week for 2 weeks [Reinhardt et al. 1971].

Vapor Pressure

363 mm Hg

Odor Threshold Low

45 ppm

Odor Threshold High

70 ppm

Lethal Concentration

LC50 (rat) = 38,500 ppm/4H

Explanatory Notes

Odor thresholds (detection at 45 ppm and recognition at 70 ppm) from CHEMINFO;

Adverse Effects
Neurotoxin

CNS Solvent Syndrome

ACGIH Carcinogen

Not Classifiable

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

Search TOXNET

Chemical Information

Search ChemIDplus

Biomedical References

Search PubMed

Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure: