Agent Name

Phorbol

CAS Number

17673-25-5

Formula

C20-H28-O6

Major Category

Biological Agents

Synonyms

1,1a,1b,4,4a,7a,7b,8,9,9a-Decahydro-4a,7b,9,9a-tetrahydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5H-cyclopropa(3,4)benz(1,2-e)azulen-5-one (1aR-(1aalpha,1bbeta,4abeta,7aalpha,7balpha,8alpha,9beta,9aalpha))-; 4,9,12-beta,13,20-Pentahydroxy-1,6-tigliadien-3-on; 4-beta-Phorbol; 4beta-Phorbol; 5H-Cyclopropa(3,4)benz(1,2-e)azulen-5-one, 1,1a,1b,4,4a,7a,7b,8,9,9a-decahydro-4a,7b,9,9a-tetrahydroxy-3-(hydroxymethyl)-1,6,8-tetramethyl-, (1aR-(1aalpha, 1beta,4abeta, 7aalpha, 7balpha, 8alpha, 9beta, 9aalpha))-; 5H-Cyclopropa(3,4)benz(1,2-e)azulen-5-one, 1,1aalpha,1bbeta,4,4a,7aalpha,7b,8,9,9a-decahydro-4abeta,7balpha,9beta,9a alpha-tetrahydroxy-3-(hydroxymethyl)-1,1,6,8alpha-tetramethyl-, (+)-; [ChemIDplus]

Category

Plant Toxins

Description

Solid; [Merck Index] White solid; [CAMEO] White powder; [MSDSonline]

Sources/Uses

Parent alcohol of tumor-promoting compounds in croton oil (expressed from seeds of Croton tiglium); [Merck Index] Used for biochemical and medical research; [Hawley]

Comments

Unlike its esters, Phorbol does not promote tumors; [HSDB] May cause skin irritation; [CAMEO] Highly toxic by inhalation, skin absorption, and ingestion; An irritant; Targets bone marrow; [Aldrich MSDS]

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