Agent Name

Phosalone

CAS Number

2310-17-0

Formula

C12-H15-Cl-N-O4-P-S2

Major Category

Pesticides

Synonyms

Agria 1060 A; 11 974 RP; 3-(6-Chloro-2-oxobenzoxazolin-3-yl)methyl O,O-diethyl phosphorothiolothionate; 3-(6-Chloro-2-oxobenzoxazolin-3-yl)methyl-O,O-diethyl phosphorothiolothionate; 3-(O,O-Diethyldithiophosphorylmethyl)-6-chlorobenzoxazolinone; 3-(O,O-Diethyldithiophosphorylmethyl)-6-chlorobenzoxazolone; 3-Diethyldithiophosphorylmethyl-6-chlorobenzoxazolone-2; 6-Chloro-3-(O,O-diethyldithiophosphorylmethyl)benzoxazolone; 6-Chloro-3-diethoxyphosphinothioylthiomethyl-1,3-benzoxazol-2(3H)-one; Agria 1060; Azofene; Benzophosphate; Benzphos; Chipman 11974; ENT 27,163; Fosalon; Fozalon; NIA-9241; NPH-1091; Niagara 9241; O,O-Diaethyl-S-(6-chlor-2-oxo-ben(b)-1,3-oxalin-3-yl)-methyl-dithiophosphat [German]; O,O-Diethyl S-((6-chloro-2-oxobenzoxazolin-3-yl)methyl) phosphorodithioate; O,O-Diethyl phosphorodithioate, S-ester with 6-chloro-3-(mercaptomethyl)-2-benzoxazolinone; O,O-Diethyl-S-((6-chloor-2-oxo-benzoxazolin-3-yl)-methyl)-dithiofosfaat [Dutch]; O,O-Diethyl-S-(6-chloro-2-oxo-benzoxazolin-3-yl)methyl-phosphorothiolothionate; O,O-Diethyl-S-(6-chloro-2-oxobenzoxazolin-3-yl-methyl)-phosphorodithioate; O,O-Diethyl-S-(6-chlorobenzoxazonyl-3-methyl) dithiophosphate; O,O-Dietil-S-((6-cloro-2-oxo-benzossazolin-3-il)-metil)-ditiofosfato [Italian]; P 974; P-974; Phosalon; Phosalone 35 EC; Phosphorodithioic acid, O,O-diethyl ester, S-ester with 6-chloro-3-(mercaptomethyl)-2-benzoxazolinone; Phosphorodithioic acid-S-ester of 6-chloro-3-mercaptomethylbenzoxazyol-2-one; Phozalon; RP 11,974; Rhodia RP 11974; Rubitox; S-((3-Benzoxazolinyl-6-chloro-2-oxo)methyl) O,O-diethyl phosphorodithioate; S-((6-Chloro-2-oxo-3(2H)-benzoxazolyl)methyl) O,O-diethyl phosphorodithioate; S-(6-Chloro-2-oxobenzoxazolin-3-yl)methyl diethyl phosphorothiolothionate; S-(6-Chloro-3-(mercaptomethyl)-2-benzoxazolinone) O,O-diethyl phosphorodithioate; S-6-Chloro-2,3-dihydro-2-oxo-1,3-benzoxazol-3-ylmethyl O,O-diethyl phosphorodithioate; S-6-Chloro-2,3-dihydro-2-oxo-benzoxazol-3-ylmethyl O,O-diethyl phosphorodithioate; Zolone; Zolone DT; Zolone PM; Zone; [ChemIDplus] UN2783

Category

Organophosphate Insecticides

Description

Colorless or white solid; [ICSC] Odor like garlic; [HSDB] White crystals; [MSDSonline]

Sources/Uses

Used as insecticide and acaricide for fruits, vegetables, ornamentals, and other crops; Still used in many countries; [HSDB] Import tolerances for almonds, grapes, apples, and other fruits grown in countries with active registrations; [Reference #1]

Comments

A skin, eye, and respiratory tract irritant; Can be absorbed through skin; A weak cholinesterase inhibitor; [ICSC] Effects in animal studies include zonal hepatitis; [RTECS] May cause skin sensitization; [eChemPortal: ESIS] The average of two baseline respective cholinesterase activity determinations three days apart, with no exposures to enzyme inhibiting pesticides for at least 30 days, is recommended for each worker prior to exposure to cholinesterase inhibitors because of large inter-individual differences in published baseline values. To be established at least once a year. Removal from workplace exposures is recommended until the cholinesterase activity returns to within 20% of baseline. [TLVs and BEIs]

Restricted

Cancelled--no longer registered as a pesticide for use in the US; [HSDB] Banned in the EU for use as pesticide for plant protection; [eChemPortal: ESIS]

Reference Link

EPA Pesticide Chemical Search

Exposure Assessment
BEI

Acetylcholinesterase activity in red blood cells = 70% of individual's baseline; Butylcholinesterase activity in serum or plasma = 60% of individual's baseline; Sample at end of shift; [TLVs and BEIs]

Vapor Pressure

4.54E-8 mm Hg

Explanatory Notes

The Guide in the Emergency Response Guidebook is for "Organophosphorus pesticide, solid, toxic."

Adverse Effects
Hepatotoxin

Hepatotoxin, Secondary

Other Poison

Organophosphate

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

Search TOXNET

Chemical Information

Search ChemIDplus

Biomedical References

Search PubMed

Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure: