| Agent Name | Phthalimide |
|---|---|
| CAS Number | 85-41-6 |
| Formula | C8-H5-N-O2 |
| Major Category | Nitrogen Compounds |
| Synonyms | 1,2-Benzenedicarboximide; 1,3-Isoindolinedione; 1H-Isoindole-1,3(2H)-dione; Benzoimide; Ftalimmide [Italian]; Isoindole-1,3-dione; Phenylimide; Phthalimid [German]; o-Phthalic imide; [ChemIDplus] |
| Category | Other Nitrogen Rings |
| Description | White solid; [Hawley] White to light tan solid; [CAMEO] White crystalline powder; [Alfa Aesar MSDS] |
| Sources/Uses | Used to make dyes, primary amines, amino acids, and Folpet (fungicide); Also used as a fungicide, laboratory reagent, and inhibitor of oxidation and photochemical reactions; [HSDB] |
| Comments | Highly irritating to skin, eyes, and upper respiratory tract; No teratogenic effects observed in rabbits at doses of 150mg/kg on days 7-12 of pregnancy; Emergency treatment: "Phthalimide fungicides"; Phthalimide fungicides include Captan and Captafol that are of "low order of acute toxicity." Both are skin sensitizers that in animal experiments can cause cancer and liver, reproductive, and developmental toxicity. [HSDB] Not irritating to skin and mildly irritating to eyes of rabbits; In 4-week inhalation study of rats, no gross, hematological, or histopathological findings; No evidence of mutagenicity; Of about twelve studies, only two produced any evidence of teratogenicity; [IUCLID] Not teratogenic in rabbits at 150 mg/kg/day; Rabbits are very sensitive to teratogenic effects of thalidomide (suspected human teratogen), of which phthalimide is a residue; [REPROTOX] An irritant; Can be absorbed through skin; [Alfa Aesar MSDS] See "Captan" and "Captafol." See "N-(Cyclohexylthio)phthalimide." |
| Exposure Assessment | |
| Vapor Pressure | 1.0E-8 mm Hg |
| Links to Other NLM Databases | |
| Health Studies | Human Health Effects from Hazardous Substances Data Bank: |
| Toxicity Information | |
| Chemical Information | |
| Related Information in HazMap | |
| Processes | Industrial Processes with risk of exposure: |
Agent Name
Phthalimide
CAS Number
85-41-6
Formula
C8-H5-N-O2
Major Category
Nitrogen Compounds
Synonyms
1,2-Benzenedicarboximide; 1,3-Isoindolinedione; 1H-Isoindole-1,3(2H)-dione; Benzoimide; Ftalimmide [Italian]; Isoindole-1,3-dione; Phenylimide; Phthalimid [German]; o-Phthalic imide; [ChemIDplus]
Category
Other Nitrogen Rings
Description
White solid; [Hawley] White to light tan solid; [CAMEO] White crystalline powder; [Alfa Aesar MSDS]
Sources/Uses
Used to make dyes, primary amines, amino acids, and Folpet (fungicide); Also used as a fungicide, laboratory reagent, and inhibitor of oxidation and photochemical reactions; [HSDB]
Comments
Highly irritating to skin, eyes, and upper respiratory tract; No teratogenic effects observed in rabbits at doses of 150mg/kg on days 7-12 of pregnancy; Emergency treatment: "Phthalimide fungicides"; Phthalimide fungicides include Captan and Captafol that are of "low order of acute toxicity." Both are skin sensitizers that in animal experiments can cause cancer and liver, reproductive, and developmental toxicity. [HSDB] Not irritating to skin and mildly irritating to eyes of rabbits; In 4-week inhalation study of rats, no gross, hematological, or histopathological findings; No evidence of mutagenicity; Of about twelve studies, only two produced any evidence of teratogenicity; [IUCLID] Not teratogenic in rabbits at 150 mg/kg/day; Rabbits are very sensitive to teratogenic effects of thalidomide (suspected human teratogen), of which phthalimide is a residue; [REPROTOX] An irritant; Can be absorbed through skin; [Alfa Aesar MSDS] See "Captan" and "Captafol." See "N-(Cyclohexylthio)phthalimide."
Exposure Assessment
Vapor Pressure
1.0E-8 mm Hg
Links to Other NLM Databases
Toxicity Information
Chemical Information
Related Information in HazMap