Agent Name

Triphenyl phosphate

CAS Number

115-86-6

Formula

C18-H15-O4-P

Major Category

Other Classes

Synonyms

Celluflex TPP; Disflamoll TP; Phenyl phosphate ((PhO)3PO); Phosflex TPP; Phosphoric acid, triphenyl ester; TP (VAN); TPP; Trifenylfosfat [Czech]; Triphenoxyphosphine oxide; Triphenyl phosphate; Triphenylphosphate; [ChemIDplus]

Category

Organophosphates, Other

Description

Colorless, crystalline powder with a phenol-like odor; [NIOSH]

Sources/Uses

Used as a plasticizer, fire-retardant, and substitute for camphor in celluloid; also used in lubricating oils and hydraulic fluids; [ACGIH]

Comments

Cholinesterase inhibition, but no cumulative toxicity, was observed in animal studies. A study of 33 workers (employed for an average of 7.4 years) in a plant manufacturing TPP found no adverse health effects. A slight reduction in erythrocyte cholinesterase activity was found in six workers. One case of occupational allergic contact dermatitis has been documented. [ACGIH] In high-dose animal studies, adverse effects include delayed paralysis similar to that seen with tri-o-cresyl phosphate. [HSDB]

Exposure Assessment
Skin Designation (ACGIH)

Insufficient data

TLV (ACGIH)

3 mg/m3

PEL (OSHA)

3 mg/m3

IDLH (NIOSH)

1000 mg/m3

Excerpts from Documentation for IDLHs

Human data: Workers exposed to an average air concentration of 3.5 mg/m3 for as long as ten years showed no evidence of adverse clinical effects [Sutton et al. 1960]. . . . Basis for revised IDLH: The revised IDLH for triphenyl phosphate is 1,000 mg/m3 based on acute oral toxicity data in animals [Antonyuk 1974].

Vapor Pressure

6.28E-6 mm Hg

Explanatory Notes

Flash point = 220 deg C;

Flammability (NFPA)

1: Must be preheated

Adverse Effects
Skin Sensitizer

Yes

ACGIH Carcinogen

Not Classifiable

Links to Other NLM Databases
Health Studies

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Toxicity Information

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Chemical Information

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent: