Agent Name

Poloxalene

CAS Number

9003-11-6

Formula

(C3-H6-O.C2-H4-O)x-

Major Category

Plastics & Rubber

Synonyms

Meroxapol 105; PEG/PPG-125/30 Copolymer; Poloxalkol; Poloxamer 101; 75-H-1400; BSP 5000; Bloat Guard; Ethylene oxide, propylene oxide block polymer; Pluronic F-127; Poloxamer 407; Polyethylene glycol, propoxylated; Polyethylene-polypropylene glycol; Polyoxyethylene-oxy-propylene [French]; Proxanol TsL-3; RC 102; SK&F 18,667; Therabloat; Glycols, polyethylene-polypropylene; Oxirane, 2-methyl-, polymer with oxirane; Oxirane, methyl-, polymer with oxirane; Poly(ethylene oxide-co-propylene oxide); Polyoxyethylene - polyoxypropylene copolymer; [ChemIDplus]

Category

Polymers

Description

Liquid; [Hawley] Cloudy paste or hazy viscous liquid; [MSDSonline]

Sources/Uses

Used as a food additive and veterinary treatment for bloat; [Hawley] Used as surfactant for pharmaceuticals; [HSDB]

Comments

A poloxamer (group of non-ionic block polymer surfactants) with an average molecular weight of 3,000; [Merck Index] Poloxalene >50% in non-hazardous diluent: An eye irritant; Toxic by ingestion; [eChemPortal: ERMA] Not irritating to skin or eyes, based on rabbit studies; [MSDSonline]

Exposure Assessment
Lethal Concentration

LC50 (rat) = 320 mg/m3/4h

Explanatory Notes

NOTE: LC50 from ChemIDplus; seems strangely low to me given LD50 > 5,000 mg/kg; no other sources list an LC50;

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Related Information in HazMap
Other Information

No other related information on this agent was found.