Agent Name

Xylidine, mixed isomers

Alternative Name

Dimethylaminobenzene

CAS Number

1300-73-8

Formula

C8-H11-N

Major Category

Nitrogen Compounds

Synonyms

Dimethylaminobenzene; Aminodimethylbenzene; Benzenamine, ar,ar-dimethyl-; Dimethylaminobenzene; Dimethylphenylamine; Xilidine [Italian]; Xylidine [Italian]; Xylidine isomers; Xylidine mixed ortho-meta-para isomers; Xylidinen [Dutch]; [ChemIDplus] UN1711

Category

Amines, Aromatic

Description

Pale-yellow to brown liquid with a weak, aromatic, amine-like odor; [NIOSH]

Sources/Uses

Used to produce dyes, drugs, and organic chemicals; [ACGIH]

Comments

Studies of experimental animals exposed at 45 ppm, 7 hours/day, 5 days a week for as long as 44 weeks showed liver injury in all animal species and methemoglobinemia in cats, dogs, and mice. No published reports on reproductive toxicity or occupational intoxications; Listed in the table "Examples of Industrial Chemicals for Which Methemoglobin Formation is NOT the Principal Cause of Toxicity"; [ACGIH] IARC classifies 2,6-xylidene as a possible human carcinogen. 2,4-xylidene and 2,5-xylidene are "not classifiable as to carcinogenicity to humans." [IARC] Inhalation of high concentrations can cause methemoglobinemia, lowering of consciousness, and may have effects on the kidneys and liver; [ICSC]

Exposure Assessment
BEI

Methemoglobin in blood = 1.5% of hemoglobin during or at end of shift. [ACGIH]

Skin Designation (ACGIH)

Yes

TLV (ACGIH)

0.5 ppm, inhalable fraction and vapor

PEL (OSHA)

5 ppm

IDLH (NIOSH)

50 ppm

Excerpts from Documentation for IDLHs

Basis for original (SCP) IDLH: The chosen IDLH is based on the mouse 7hour LC50 of 149 ppm [von Oettingen et al. 1947 cited by ACGIH 1971]. . . . Human data: None relevant for use in determining the revised IDLH;

Vapor Pressure

0.13 mm Hg

Odor Threshold Low

0.005 ppm

Lethal Concentration

LC50 (mice) = 149 ppm/7 hr

Explanatory Notes

Odor threshold from CHEMINFO; Flash point = 206 deg F;

Flammability (NFPA)

1: Must be preheated

Adverse Effects
Hepatotoxin

Hepatotoxin, Secondary

Methemoglobinemia

Methemoglobinemia, Secondary

ACGIH Carcinogen

Confirmed Animal

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Related Information in HazMap
Other Information

No other related information on this agent was found.