Agent Name

Dinitrophenol

CAS Number

25550-58-7

Formula

C6-H4-N2-O5

Major Category

Nitrogen Compounds

Synonyms

Dinitroaminophenol; Phenol, dinitro-; p-Dinitrophenol; Dinitrophenol solutions; [ChemIDplus] UN0076; UN1320; UN1599

Category

Nitrophenols

Description

Yellow solid; [Hawley]

Sources/Uses

Used in the manufacturing of dyes, wood preservatives, and insecticides; used as "a reagent for the detection of potassium and ammonium ions"; [HSDB] Nitrophenolic and nitrocresolic herbicides are used in some parts of the world as acaricides, nematocides, ovicides, and fungicides. "Only dinocap continues to have active registrations in the United States." [EPA Pesticides, p. 104] Used to make diaminophenol hydrochloride (photographic developer) and explosives; [Hawley]

Comments

May cause skin burns; [HSDB] The pathophysiology, like that of pentachlorophenol, involves the uncoupling of oxidative phosphorylation. Yellow stains appear on the skin after dermal contact with the nitroaromatic herbicides. Fatal poisoning can occur after dermal absorption. Cataracts have been reported in animal experiments and after occupational exposure. In severe poisoning, these herbicides can cause injury to the liver and kidneys. [EPA Pesticides, p. 104-5] Secondary acute renal failure after dinitrophenol and dinitro-o-cresol poisoning has been reported. [LaDou, p. 418] There is a case report of dinitrophenol causing cholestatic jaundice. [Zimmerman, p. 351] Listed in table of "Methemoglobinemia-inducing agents: industrial, environmental, and pharmaceutical"; [Sullivan, p. 729] Solid form can cause first degree burns after short skin exposure; [CHRIS] Extremely hazardous explosion hazard when dry; [Hawley]

Restricted

Emergency suspension & cancellation of registration as herbicide in 1986.

Exposure Assessment
Vapor Pressure

1.2E-5 mm Hg

Explanatory Notes

The Guide in the Emergency Response Guidebook is for UN1599: "Dinitrophemol, solution." UN1320 (Guide 113) is for "Dinitrophenol, wetted with not less than 15% water."

Reference Link

ATSDR - ToxFAQs - Dinitrophenols

Adverse Effects
Hepatotoxin

Hepatotoxin, Secondary

Nephrotoxin

Yes

Methemoglobinemia

Methemoglobinemia, Secondary

Other Poison

Uncoupler

Dermatotoxin

Skin Burns

Links to Other NLM Databases
Health Studies

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Toxicity Information

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Chemical Information

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure: