Agent Name

Profenofos

CAS Number

41198-08-7

Formula

C11-H15-Br-Cl-O3-P-S

Major Category

Pesticides

Synonyms

CGA 15324; Curacron; O-(4-Bromo-2-chlorophenyl)-O-ethyl-S-propyl phosphorothioate; Phosphorothioic acid, O-(4-bromo-2-chlorophenyl) O-ethyl S-propyl ester (9CI); Phosphorothioic acid, O-(4-bromo-2-chlorophenyl)-O-ethyl S-propyl ester; Polycron; Selecron; [ChemIDplus]

Category

Organophosphate Insecticides

Description

Pale yellow or amber liquid with an odor like garlic; [HSDB]

Sources/Uses

Used as insecticide and acaricide for cotton and vegetables; [Merck Index] Only used on cotton in the US; [Reference #1]

Comments

A human cholinesterase inhibitor; Caused morphological changes and decrease in count and motility to mice sperm after five days of dosing; Liver function affected by acute and sub-chronic dosing in rabbits based on enzyme testing; [HSDB] Lower ratio of symptomatic human poisoning cases reported per pound of usage than other cholinesterase inhibiting pesticides; [Reference #1]

Restricted

A restricted use pesticide in the US; [Reference #1]

Reference Link

EPA Pesticide Chemical Search

Exposure Assessment
BEI

Cholinesterase activity in red cells = 70% of individual's baseline, sample time discretionary; [ACGIH]

Vapor Pressure

9.0E-7 mm Hg

Lethal Concentration

LC50 (rat) = 3,000 mg/m3/4h

Reference Link

INCHEM JMPR: Profenofos - 1990

Adverse Effects
Hepatotoxin

Hepatotoxin, Secondary

Other Poison

Organophosphate

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Biomedical References

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure: