Agent Name

Profenofos

CAS Number

41198-08-7

Formula

C11-H15-Br-Cl-O3-P-S

Major Category

Pesticides

Synonyms

CGA 15324; Curacron; O-(4-Bromo-2-chlorophenyl)-O-ethyl-S-propyl phosphorothioate; Phosphorothioic acid, O-(4-bromo-2-chlorophenyl) O-ethyl S-propyl ester (9CI); Phosphorothioic acid, O-(4-bromo-2-chlorophenyl)-O-ethyl S-propyl ester; Polycron; Selecron; [ChemIDplus]

Category

Organophosphate Insecticides

Description

Pale yellow or amber liquid with an odor like garlic; [HSDB]

Sources/Uses

Used as insecticide and acaricide for cotton and vegetables; [Merck Index] Only used on cotton in the US; [Reference #1]

Comments

A human cholinesterase inhibitor; Caused morphological changes and decrease in count and motility to mice sperm after five days of dosing; Liver function affected by acute and sub-chronic dosing in rabbits based on enzyme testing; [HSDB] Lower ratio of symptomatic human poisoning cases reported per pound of usage than other cholinesterase inhibiting pesticides; [Reference #1] The average of two baseline respective cholinesterase activity determinations three days apart, with no exposures to enzyme inhibiting pesticides for at least 30 days, is recommended for each worker prior to exposure to cholinesterase inhibitors because of large inter-individual differences in published baseline values. To be established at least once a year. Removal from workplace exposures is recommended until the cholinesterase activity returns to within 20% of baseline. [TLVs and BEIs]

Restricted

A restricted use pesticide in the US; [Reference #1]

Reference Link

EPA Pesticide Chemical Search

Exposure Assessment
BEI

Acetylcholinesterase activity in red blood cells = 70% of individual's baseline; Butylcholinesterase activity in serum or plasma = 60% of individual's baseline; Sample at end of shift; [TLVs and BEIs]

Vapor Pressure

9.0E-7 mm Hg

Lethal Concentration

LC50 (rat) = 3,000 mg/m3/4h

Reference Link

INCHEM JMPR: Profenofos - 1990

Adverse Effects
Hepatotoxin

Hepatotoxin, Secondary

Other Poison

Organophosphate

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Biomedical References

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure: