Agent Name

Propyl gallate

CAS Number

121-79-9

Formula

C10-H12-O5

Major Category

Other Uses

Synonyms

3,4,5-Trihydroxybenzene-1-propylcarboxylate; 3,4,5-Trihydroxybenzoic acid n-propyl ester; 3,4,5-Trihydroxybenzoic acid, propyl ester; Benzoic acid, 3,4,5-trihydroxy-, propyl ester; Gallic acid, propyl ester; Nipa 49; Nipagallin P; Progallin P; Propyl 3,4,5-trihydroxybenzoate; Propylester kyseliny gallove [Czech]; Tenox PG; n-Propyl 3,4,5-trihydroxybenzoate; n-Propyl ester of 3,4,5-trihydroxybenzoic acid; n-Propyl gallate; [ChemIDplus]

Category

Preservatives

Description

Colorless or white odorless solid; [HSDB] Faintly beige crystals; [MSDSonline]

Sources/Uses

Used as antioxidant to prevent rancidity in fats, oils, and other food products; Also used as a laboratory reagent and stabilizer for synthetic vitamin A; [HSDB] Used as an antioxidant for cosmetics, ethers, emulsions, waxes, and transformer oils; [Merck Index] Contact dermatitis documented in a baker and confectioner; [Kanerva, p. 1830]

Comments

Cause allergic contact dermatitis in bakers and other workers; [HSDB] A skin, eye, mucous membrane, and upper respiratory tract irritant; May cause skin sensitization; [CAMEO] Causes convulsions in lethal dose studies of rats; [RTECS] May cause skin sensitization; [eChemPortal: ESIS] Does not increase birth defects in animal experiments; [REPROTOX] ADI = 0-1.4 mg/kg when used as an antioxidant in food; [JECFA]

Reference Link

Allergic contact dermatitis to propyl gallate. [Contact Dermatitis. 1987] - PubMed result

Adverse Effects
Skin Sensitizer

Yes

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Biomedical References

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent: