Agent Name

Dimethylaminopropionitrile

CAS Number

1738-25-6

Formula

C5-H10-N2

Major Category

Nitrogen Compounds

Synonyms

3-(Dimethylamino)propanenitrile; 3-(Dimethylamino)propionitrile; 3-(N,N-Dimethylamino)propionitrile; 3-Dimethylaminopropannitril [Czech]; Dmapn; N,N-(Dimethylamino)-3-propionitrile; Propanenitrile, 3-(dimethylamino)-; Propionitrile, 3-(dimethylamino)-; beta-(N-Dimethylamino)propionitrile; beta-Dimethylaminopropionitrile; [ChemIDplus]

Category

Nitriles

Description

Colorless liquid; [NIOSH]

Sources/Uses

Dimethylaminopropionitrile was a component of catalysts used in manufacture of flexible polyurethane foams. [LaDou, p. 500]

Comments

Workers at polyurethane production plants developed neurogenic bladder dysfunction after exposure to the catalyst. [LaDou, p. 500] "A skin and eye irritant."; [HSDB] Symptoms of workers included erectile dysfunction and urinary retention. Cystometrograms confirmed neurogenic bladder. In follow-up studies 2 years later, 11 workers were still symptomatic with bladder and sexual dysfunction. A smaller group still had evidence of sensory neuropathy. [Rom, p. 644] See "NIAX catalyst ESN." See ""Propionitrile."

Restricted

Production of catalysts containing this chemical was discontinued after 1978; [Ladou, p. 500]

Exposure Assessment
Explanatory Notes

VP = 10 mmHg @ 135 degrees F; Flash point = 147 deg F;

Flammability (NFPA)

2: High ambient temperature required

Adverse Effects
Neurotoxin

Sensorimotor Neuropathy

Other Poison

Chemical Asphyxiant

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Other Information

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