Agent Name

Riddelline

CAS Number

23246-96-0

Formula

C18-H23-N-O6

Major Category

Biological Agents

Synonyms

Riddelliin; Riddelliine; (1,6)Dioxacyclododecino(2,3,4-gh)pyrrolizine-2,7-dione, 3-ethylidene-3,4,5,6,9,11,13,14,14a,14b-decahydro-6-hydroxy-6-(hydroxymethyl)-5-methylene-, (3Z,6S,14aR,14bR)-; 13,19-Didehydro-12,18-dihydroxysenecionan-11,16-dione; Senecionan-11,16-dione, 13,19-didehydro-12,18-dihydroxy- (9CI); [ChemIDplus] UN1544

Category

Plant Toxins

Description

Colorless solid; [INCHEM] Colorless to off white solid; [CAMEO]

Sources/Uses

A pyrrolizidine alkaloid found in the plant species Senecio; Formerly used in Europe as a herbal remedy for dysmenorrhea and amenorrhea, and in the US as a diuretic and tonic; No known current uses; [INCHEM]

Comments

Emergency treatment: "Plants- pyrrolizidine alkaloids"; [HSDB] Poisonings from Senecio vulgaris L. have caused severe liver damage and failure; "In man, poisoning is manifested as acute veno-occlusive disease, leading to hepatomegaly, ascites, massive pleural effusion, and in many cases progressing to cirrhosis. Some metabolites are released into the circulation and are believed to pass beyond the liver to the lung causing vascular lesions. The pyrrolic metabolites are cytotoxic and act on the hepatocytes and on the endothelium of blood vessels of the liver and lung. From evidence in experimental animals and circumstantial evidence in one human case report, the possibility of toxic pulmonary disease in man cannot be ruled out." [Reference #1] "Symptoms of acute exposure to a mixture containing this compound include abdominal pain, hepatomegaly, emaciation, nausea, diarrhea and liver cirrhosis. Death occurred in several cases. Ingestion of mixtures in which this compound is a component has caused infant hepatic veno-occlusive disease and early death." [CAMEO]

Reference Link

INCHEM: Senecio Vulgaris L. (PIM 484 - peer review 1990)

Exposure Assessment
Explanatory Notes

The Guide in the Emergency Response Guidebook is for "Alkaloids, solid, n.o.s. (poisonous)."

Adverse Effects
Hepatotoxin

Hepatotoxin, Secondary

NTP Carcinogen

Anticipated Human Carcinogen

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Related Information in HazMap
Other Information

No other related information on this agent was found.