Agent Name

Rinderine

CAS Number

6029-84-1

Formula

C15-H25-N-O5

Major Category

Biological Agents

Synonyms

Butanoic acid, 2,3-dihydroxy-2-(1-methylethyl)-, (2,3,5,7a-tetrahydro-1-hydroxy-1H-pyrrolizin-7-yl)methyl ester, (1S-(1alpha,7(2R*,3S*),7aalpha))-; [ChemIDplus]

Category

Plant Toxins

Sources/Uses

More than 350 pyrrolizidine alkaloids (PAs) in over 6000 plants have been identified. They are probably the most common cause of plant poisoning in the world and affect livestock, wildlife, and humans. They are found in the Boraginaceae, Compositae, and Leguminosae families and are commonly encountered in the following plants: fiddle neck, tarweed, rattle box, blue weed, giant hog weed, heliotrope, groundsels, Senecio, and comfrey. [Haddad, p. 494] Liver disease from "bush tea" derived from the Crotalaria plant is endemic in Jamaica. Cereal contaminated with PA seeds (Heliotropium and Crotalaria) have caused epidemics in Afghanistan and India. Herbal remedies that have caused liver disease include Senecio and comfrey. [Goldfrank, p. 647]

Comments

Emergency treatment: "Plants- pyrrolizidine alkaloids"; Pyrrolizidine alkaloids (PAs) cause veno-occlusive liver disease. Diagnosis is difficult because symptoms may be delayed for days or weeks. After drinking herbal tea or eating plants contaminated with seeds of PA plants, symptoms may include vomiting, abdominal pain, hepatomegaly, and later ascites. Jaundice may be present. Children may appear to have Reye's syndrome. [HSDB] The liver is the target organ. Plants containing significant amounts of pyrrolizidine alkaloids are found all over the world, comprising about 3% of all flowering plants. They have long been known to be toxic to livestock. Outbreaks of poisoning cases in humans after food contamination have been reported, and the problem is endemic in some central Asian republics. [Reference #1] Teas containing PAs include coltsfoot, comfrey, gordolobo, groundsel, mate, tansy ragwort, and T'u-san-chi. The teas may be prescribed as herbal remedies for anxiety or amenorrhea. The alkaloid is concentrated in the root of the plants. As little as 85 mg may be toxic. [Haddad, p. 1082] PAs also cause cirrhosis and possibly hepatic carcinoma. [Goldfrank, p. 647]

Adverse Effects
Hepatotoxin

Hepatotoxin, Secondary

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